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USP47 Knockout Cell Lines

Gene: USP47

Official Full Name: ubiquitin specific peptidase 47provided by HGNC

Gene Summary: Enables WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of macromolecule metabolic process; and positive regulation of canonical Wnt signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12723 USP47 Knockout cell line (HeLa) Human USP47 1:3~1:6 Negative Online Inquiry
KO12724 USP47 Knockout cell line (HCT 116) Human USP47 1:2~1:4 Negative Online Inquiry
KO12725 USP47 Knockout cell line (HEK293) Human USP47 1:3~1:6 Negative Online Inquiry
KO12726 USP47 Knockout cell line (A549) Human USP47 1:3~1:4 Negative Online Inquiry

Background

USP47 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone genetic modification to silence the expression of the USP47 gene, which encodes a deubiquitinating enzyme involved in cellular signaling and protein regulation. These knockout cell lines represent a powerful tool for researchers studying the myriad roles of USP47 in various biological processes, including cell proliferation, differentiation, and response to stress.

The primary function of the USP47 Gene Knockout Cell Lines is to facilitate the investigation of USP47's impact on protein degradation pathways. By removing the functional gene, researchers can observe the subsequent alterations in ubiquitin-mediated processes and their downstream effects on cellular functions. The disruption of USP47 offers insights into its role in pathologies such as cancer, neurodegenerative disorders, and immune system regulation, thereby revealing potential therapeutic targets for drug development.

In research and clinical applications, knockout cell lines serve as pivotal systems for drug screening, functional genomics, and pathway elucidation, enabling scientists to dissect complex biological networks that govern cell behavior. The USP47 Gene Knockout Cell Lines stand out because they provide high fidelity in gene disruption, allowing for reproducible experimental outcomes. This precision is crucial for generating reliable data, which can significantly accelerate the discovery of novel biomolecular interactions and therapeutic interventions.

The value of these cell lines to researchers and clinicians lies in their ability to uncover the mechanistic roles of USP47 in health and disease, paving the way for innovative treatments. Moreover, their application extends beyond basic research; they can be effectively utilized in pharmacological studies aimed at identifying compounds that modulate USP47 activity, thus offering a translational pathway from bench to bedside.

Our company specializes in providing high-quality genetic models and is committed to advancing research through state-of-the-art scientific products. We pride ourselves on the expertise and innovation that underpin our offerings, ensuring that researchers have access to the tools they need to drive scientific discovery forward.

Please note that all services are for research use only. Not intended for any clinical use.

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