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USP34 Knockout Cell Lines

Gene: USP34

Official Full Name: ubiquitin specific peptidase 34provided by HGNC

Gene Summary: Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32840 USP34 Knockout cell line (HeLa) Human USP34 1:3~1:6 Negative Online Inquiry
KO32841 USP34 Knockout cell line (HCT 116) Human USP34 1:2~1:4 Negative Online Inquiry
KO32842 USP34 Knockout cell line (HEK293) Human USP34 1:3~1:6 Negative Online Inquiry
KO32843 USP34 Knockout cell line (A549) Human USP34 1:3~1:4 Negative Online Inquiry

Background

USP34 Gene Knockout Cell Lines are highly specialized cellular models engineered to lack the expression of the USP34 gene, which encodes a deubiquitinating enzyme involved in the regulation of various cellular processes. These cell lines are crucial tools for researchers seeking to investigate the role of USP34 in cellular signaling, proliferation, and the broader implications in oncogenic pathways. By providing a platform that mimics the absence of USP34, these knockout lines enable the examination of gene function and the elucidation of molecular mechanisms that are often obscured in wild-type cells.

The key function of the USP34 Gene Knockout Cell Lines lies in their ability to provide insights into the impact of ubiquitination processes on cell fate decisions. Ubiquitination is a pivotal regulatory mechanism that influences protein stability and activity, and the loss of USP34 can reveal compensatory pathways or alternate signaling cascades activated in its absence. Researchers can utilize these cell lines to perform targeted experiments, including gene expression analysis, proteomic studies, and drug response assessments, facilitating a better understanding of the intricate web of cellular interactions.

The scientific importance of USP34 Gene Knockout Cell Lines extends to both basic research and clinical relevance. They can be utilized to model diseases such as cancer, neurodegenerative disorders, and other pathologies linked to dysregulated ubiquitin-proteasome systems. Furthermore, these cell lines can serve as an invaluable resource in drug discovery efforts, enabling the identification of potential therapeutic targets and biomarkers.

What sets USP34 Gene Knockout Cell Lines apart from alternatives is their rigorously validated knockout models that ensure the specificity and reliability of results. These cell lines are thoroughly characterized for successful gene modification, providing confidence in experimental outcomes. Additionally, they are easily compatible with a wide range of assays, making them versatile tools in both high-throughput and more detailed experimental frameworks.

Researchers and clinicians seeking to explore the nuanced roles of ubiquitin signaling will find the USP34 Gene Knockout Cell Lines indispensable. The ability to elucidate complex biological mechanisms not only deepens our understanding but also opens new avenues for targeted therapies.

Our company prides itself on delivering high-quality biological products that empower scientific discovery. With a commitment to excellence and innovation in life sciences, we continuously strive to support researchers in their pursuit of groundbreaking findings.

Please note that all services are for research use only. Not intended for any clinical use.

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