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USP3 Knockout Cell Lines

Gene: USP3

Official Full Name: ubiquitin specific peptidase 3provided by HGNC

Gene Summary: Enables deubiquitinase activity and histone binding activity. Involved in DNA repair and DNA repair-dependent chromatin remodeling. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32442 USP3 Knockout cell line (HeLa) Human USP3 1:3~1:6 Negative Online Inquiry
KO32443 USP3 Knockout cell line (HCT 116) Human USP3 1:2~1:4 Negative Online Inquiry
KO32444 USP3 Knockout cell line (HEK293) Human USP3 1:3~1:6 Negative Online Inquiry
KO32445 USP3 Knockout cell line (A549) Human USP3 1:3~1:4 Negative Online Inquiry

Background

USP3 Gene Knockout Cell Lines are meticulously developed cellular models with the USP3 gene specifically disrupted, allowing researchers to explore the biological functions and pathways influenced by ubiquitin-specific protease 3 (USP3). USP3 plays a critical role in regulating protein turnover and cellular signaling through deubiquitination, thus its knockout serves to elucidate its contributions to various pathological states, including cancer and neurodegenerative diseases.

The key function of these cell lines lies in their ability to simulate conditions where USP3 activity is absent. This makes them instrumental for studying the consequences of USP3 loss on cellular processes such as apoptosis, cell cycle progression, and stress response pathways. By providing a controlled environment for these investigations, the cell lines facilitate the identification of downstream targets and elucidation of compensatory mechanisms employed by the cell in response to USP3 disruption.

The scientific importance of USP3 Gene Knockout Cell Lines is underscored in both research and clinical applications. In research, they serve as powerful tools to dissect molecular mechanisms orchestrated by USP3 and contribute to the understanding of diseases. Clinically, insights gained from studies utilizing these knockout cell lines may inform the development of targeted therapies, particularly in oncology, where USP3's role in tumor progression is increasingly recognized.

What sets USP3 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification, validated knockout efficacy, and the accompanying comprehensive data characterizing cellular changes upon USP3 loss, which enhance research reproducibility and reliability. This specificity ensures that results derived from studies using these cell lines are robust and directly applicable in understanding USP3’s functional roles.

For researchers and clinicians, investing in USP3 Gene Knockout Cell Lines means gaining access to a premium product that not only enables groundbreaking research but also has the potential to translate into actionable clinical insights. Our company boasts extensive expertise in developing biologically relevant cell lines, providing invaluable resources for the scientific community engaged in gene function studies and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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