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USP25 Knockout Cell Lines

Gene: USP25

Official Full Name: ubiquitin specific peptidase 25provided by HGNC

Gene Summary: Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00605 USP25 gRNA5-gRNA6 KO plasmid USP25 $850
KO00824 USP25 Knockout cell line(HCT 116) Human USP25 1:2~1:4 Negative Online Inquiry
KO12750 USP25 Knockout cell line (HeLa) Human USP25 1:3~1:6 Negative Online Inquiry
KO12751 USP25 Knockout cell line (HEK293) Human USP25 1:3~1:6 Negative Online Inquiry
KO12752 USP25 Knockout cell line (A549) Human USP25 1:3~1:4 Negative Online Inquiry

Background

USP25 Gene Knockout Cell Lines are specialized biological reagents developed for advanced genomic studies, specifically facilitating the functional analysis of the USP25 gene. These cell lines are created by employing state-of-the-art CRISPR/Cas9 technology to achieve a precise knockout of the USP25 gene, which encodes a ubiquitin-specific protease critical in diverse cellular processes, such as protein degradation, signal transduction, and cellular stress response.

The primary function of USP25 is its role in modulating the ubiquitin-proteasome pathway, consequently influencing cellular homeostasis and proteostasis. By utilizing these knockout cell lines, researchers can effectively study the implications of USP25 deficiency on various cellular mechanisms, including its impact on cell survival, differentiation, and response to drugs. This allows for a deeper understanding of the gene's role in disease models, particularly cancer, neurodegenerative disorders, and immune responses.

The scientific importance of USP25 Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings. They serve as invaluable tools for drug discovery, biomarker identification, and therapeutic development, assisting researchers in unraveling the complexities of gene function and interaction. Moreover, these cell lines provide a superior alternative to traditional methods, such as RNA interference, offering greater specificity and permanence in gene editing.

Unique advantages of our USP25 Gene Knockout Cell Lines include comprehensive characterization and validation processes to ensure optimal performance in experimental settings. Their ease of use, compatibility with various assay formats, and robust handling protocols set them apart from competitors. Researchers and clinicians can rely on these cell lines for consistent results, streamlining their experimental workflows while enhancing reproducibility.

Ultimately, the USP25 Gene Knockout Cell Lines are essential for advancing genomic research and drug development. With our company’s expertise in gene editing technologies and a commitment to providing high-quality biological products, we deliver solutions that empower scientists to conduct pioneering research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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