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USP16 Knockout Cell Lines

Gene: USP16

Official Full Name: ubiquitin specific peptidase 16provided by HGNC

Gene Summary: This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01808 USP16 Knockout cell line (HeLa) Human USP16 1:3~1:6 Negative Online Inquiry
KO01809 USP16 Knockout cell line (HCT 116) Human USP16 1:2~1:4 Negative Online Inquiry
KO01810 USP16 Knockout cell line (HEK293) Human USP16 1:3~1:6 Negative Online Inquiry
KO01811 USP16 Knockout cell line (A549) Human USP16 1:3~1:4 Negative Online Inquiry

Background

USP16 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the USP16 gene, a significant player in cellular processes such as growth regulation, cell cycle control, and protein deubiquitination. This unique modification allows researchers to investigate the functional consequences of USP16 deficiency, shedding light on its role in various biological processes and disease states. The knockout mechanism is achieved through cutting-edge gene editing technologies, such as CRISPR/Cas9, ensuring precise and stable genomic alterations.

The key functions of these cell lines revolve around their ability to facilitate studies regarding the molecular pathways affected by USP16. Researchers can examine alterations in cellular proliferation, apoptosis, and response to therapeutic agents, particularly in cancer research where USP16 is implicated in tumorigenesis. Moreover, these cell lines serve as essential tools for investigating the pathophysiology of various disorders related to ubiquitin-mediated proteostasis.

Scientifically, the importance of USP16 Gene Knockout Cell Lines cannot be overstated; they enhance our understanding of the ubiquitin-proteasome system and its contribution to cellular homeostasis. Their applications are extensive, ranging from basic biological research to potential clinical applications in drug development and targeted therapies. Compared to traditional knockout methods, these cell lines offer a higher efficiency and specificity, streamlining research workflows.

Researchers, clinicians, and pharmaceutical companies will find immense value in using USP16 Gene Knockout Cell Lines as they enable the exploration of new therapeutic targets and the design of targeted interventions. With our company’s commitment to providing high-quality biological products, backed by a team of experienced scientists, we ensure that our gene knockout cell lines meet the rigorous standards required for innovative and impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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