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USO1 Knockout Cell Lines

Gene: USO1

Official Full Name: USO1 vesicle transport factorprovided by HGNC

Gene Summary: The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34009 USO1 Knockout cell line (HeLa) Human USO1 1:3~1:6 Negative Online Inquiry
KO34010 USO1 Knockout cell line (HCT 116) Human USO1 1:2~1:4 Negative Online Inquiry
KO34011 USO1 Knockout cell line (HEK293) Human USO1 1:3~1:6 Negative Online Inquiry
KO34012 USO1 Knockout cell line (A549) Human USO1 1:3~1:4 Negative Online Inquiry

Background

USO1 Gene Knockout Cell Lines represent a pioneering approach in cellular research, specifically tailored to study the USO1 gene's role in intracellular transport mechanisms and Golgi function. Utilizing CRISPR/Cas9 gene editing technology, these cell lines have been engineered to contain a complete knockout of the USO1 gene, enabling researchers to investigate the biological consequences of its absence in various cellular contexts.

The key function of USO1 is to facilitate the tethering of vesicles to the Golgi apparatus, thus playing a critical role in maintaining Golgi architecture and function. By studying these knockout cell lines, scientists can gain insights into pathways of vesicular transport, protein sorting, and Golgi integrity, offering a comprehensive understanding of cellular dynamics under various physiological and pathological conditions.

The scientific importance of USO1 Gene Knockout Cell Lines extends to both research and clinical applications. In research settings, they serve as invaluable tools for dissecting the molecular mechanisms associated with Golgi-related diseases, including certain genetic disorders and cancer biogenesis. Clinically, understanding the role of USO1 may facilitate the development of therapeutic strategies targeting Golgi dysfunctions.

What sets our USO1 Gene Knockout Cell Lines apart from other genetic models is our commitment to high-quality validation and performance. Each cell line undergoes rigorous testing for gene editing efficiency, off-target effects, and functional studies, ensuring reliable results. This level of assurance promotes confidence among researchers who require precision for their experiments.

For researchers, clinicians, and industry professionals, these cell lines offer a unique opportunity to advance their understanding of cellular transport phenomena and contribute to the burgeoning field of cell biology. Our company prides itself on its extensive expertise in genetic engineering and biological product development, ensuring that each product not only meets but exceeds scientific standards, ultimately bridging gaps in research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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