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UROS Knockout Cell Lines

Gene: UROS

Official Full Name: uroporphyrinogen III synthaseprovided by HGNC

Gene Summary: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34831 UROS Knockout cell line (HeLa) Human UROS 1:3~1:6 Negative Online Inquiry
KO34832 UROS Knockout cell line (HCT 116) Human UROS 1:2~1:4 Negative Online Inquiry
KO34833 UROS Knockout cell line (HEK293) Human UROS 1:3~1:6 Negative Online Inquiry
KO34834 UROS Knockout cell line (A549) Human UROS 1:3~1:4 Negative Online Inquiry

Background

UROS Gene Knockout Cell Lines are a revolutionary tool in genetic research, specifically designed to facilitate the investigation of gene function and the development of targeted therapies. These cell lines are engineered to lack the UROS (urogenital somatic) gene, which plays a crucial role in porphyrin metabolism. By knocking out this gene, researchers can better understand its biological significance, as well as the pathways related to porphyrias and other metabolic disorders.

The key function of UROS Gene Knockout Cell Lines lies in their ability to serve as a model system to investigate the consequences of gene absence. This is achieved by utilizing advanced CRISPR-Cas9 technology for precise genome editing, thereby allowing for the study of alterations in metabolic pathways and their functional implications. Through these models, scientists can assess changes in enzymatic activity, metabolic profiles, and develop screening assays for potential therapeutic compounds.

The scientific importance of UROS Gene Knockout Cell Lines cannot be overstated. They not only provide insights into the molecular mechanisms underlying genetic disorders but also enable researchers to develop and test novel interventions in preclinical studies. Their application extends to drug discovery, toxicology testing, and gene therapy research in both academic and clinical settings.

Compared to alternative products, UROS Gene Knockout Cell Lines offer unique advantages such as robust genetic validation, a stable cellular environment, and versatile applications in various experimental conditions. These attributes are crucial for producing reliable, reproducible results that are essential for advancing scientific knowledge and therapeutic development.

For researchers and clinicians, the value of UROS Gene Knockout Cell Lines is evident; they provide an invaluable resource for elucidating gene function and unraveling complex biological processes. Our commitment to excellence in biological product development ensures that we deliver high-quality, well-characterized cellular models that can significantly enhance your research and clinical applications. With a strong foundation in genetic engineering and a deep understanding of cellular biology, our expertise supports your journey in groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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