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UQCR10 Knockout Cell Lines

Gene: UQCR10

Official Full Name: ubiquinol-cytochrome c reductase, complex III subunit Xprovided by HGNC

Gene Summary: UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27042 UQCR10 Knockout cell line (HeLa) Human UQCR10 1:3~1:6 Negative Online Inquiry
KO27043 UQCR10 Knockout cell line (HCT 116) Human UQCR10 1:2~1:4 Negative Online Inquiry
KO27044 UQCR10 Knockout cell line (HEK293) Human UQCR10 1:3~1:6 Negative Online Inquiry

Background

UQCR10 Gene Knockout Cell Lines are genetically engineered cell models that have undergone the targeted deletion of the UQCR10 gene, which encodes a crucial component of the mitochondrial respiratory chain. This gene plays a pivotal role in facilitating electron transfer and the generation of adenosine triphosphate (ATP) within the mitochondria, making it essential for cellular energy metabolism. The UQCR10 knockout provides researchers with a potent tool to study mitochondrial dysfunction and its implications in various diseases, particularly those associated with metabolic disorders and neurodegenerative diseases.

The mechanisms by which UQCR10 knockout cell lines operate allow scientists to investigate the downstream effects of altered mitochondrial function. By eliminating the UQCR10 gene, these cell lines exhibit compromised oxidative phosphorylation, leading to a cascade of metabolic changes. Researchers can utilize these changes to delve into pathways implicated in apoptosis, energy metabolism, and cellular stress responses. This model provides profound insights into conditions such as cancer, where altered mitochondrial function plays a role, and understanding these connections can guide the development of therapeutic strategies.

In comparison with traditional knockout strategies that may result in off-target effects or incomplete gene deletions, UQCR10 Gene Knockout Cell Lines offer specificity and reliability, enhancing the validity of experimental outcomes. This precision allows researchers to confidently attribute observed phenotypic changes directly to the absence of UQCR10, making it a valuable asset in both basic research and clinical studies.

The importance of this product lies in its capacity to bridge gaps in our understanding of mitochondrial biology and disease. By utilizing UQCR10 knockout cell lines, researchers and clinicians gain access to an innovative system that can aid in the development of mitochondrial-targeted therapies and diagnostic tools.

Our company is committed to advancing scientific research by providing high-quality biological products that empower researchers to uncover the complexities of cellular processes, such as the UQCR10 Gene Knockout Cell Lines, which exemplify our dedication to excellence in genetic tools and model systems.

Please note that all services are for research use only. Not intended for any clinical use.

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