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UQCC1 Knockout Cell Lines

Gene: UQCC1

Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 1provided by HGNC

Gene Summary: This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12787 UQCC1 Knockout cell line (HeLa) Human UQCC1 1:3~1:6 Negative Online Inquiry
KO12788 UQCC1 Knockout cell line (HCT 116) Human UQCC1 1:2~1:4 Negative Online Inquiry
KO12789 UQCC1 Knockout cell line (HEK293) Human UQCC1 1:3~1:6 Negative Online Inquiry
KO12790 UQCC1 Knockout cell line (A549) Human UQCC1 1:3~1:4 Negative Online Inquiry

Background

UQCC1 Gene Knockout Cell Lines are highly specialized human cell lines engineered to lack the expression of the UQCC1 (Ubiquinol-Cytochrome C Reductase Core Protein 1) gene. This gene plays a critical role in mitochondrial function and cellular energy metabolism. By utilizing CRISPR-Cas9 technology, these cell lines facilitate the study of UQCC1-related pathways, enabling researchers to investigate the implications of gene disruption on cellular processes such as oxidative stress, apoptosis, and metabolic dysregulation.

The key function of UQCC1 is its involvement in the electron transport chain, a critical component of mitochondrial ATP production. By knocking out the UQCC1 gene, researchers can elucidate the downstream effects on mitochondrial activity, reactive oxygen species production, and overall cellular health. This model proves invaluable in examining disease states, particularly those linked to mitochondrial dysfunction, including neurodegenerative diseases and certain types of cancer.

The scientific importance of UQCC1 Gene Knockout Cell Lines lies in their ability to provide a clearer understanding of the genetic underpinnings of diseases. These cell lines serve as a powerful tool in preclinical studies and therapeutic development, allowing for targeted drug testing and validation of novel anti-cancer compounds. By providing insights into the mechanisms of action and potential resistance pathways, they enable the identification of more effective therapies tailored to specific patient profiles.

Compared to traditional methods of gene manipulation, UQCC1 Gene Knockout Cell Lines offer superior precision and reproducibility. They are rigorously validated for consistency and performance, ensuring that researchers obtain reliable and interpretable results. Furthermore, these cell lines are readily accessible and come with comprehensive technical support, allowing for seamless integration into existing workflows.

In a landscape where understanding mitochondrial dynamics is becoming increasingly crucial, the UQCC1 Gene Knockout Cell Lines provide researchers and clinicians with an innovative resource that bridges the gap between fundamental biology and practical application. Our company specializes in producing high-quality biological products that cater to the needs of professionals in the life sciences. With our expertise in genetic engineering and commitment to excellence, we continue to empower research that enhances the understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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