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UNC93B1 Knockout Cell Lines

Gene: UNC93B1

Official Full Name: unc-93 homolog B1, TLR signaling regulatorprovided by HGNC

Gene Summary: This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25674 UNC93B1 Knockout cell line (HeLa) Human UNC93B1 1:3~1:6 Negative Online Inquiry
KO25675 UNC93B1 Knockout cell line (HCT 116) Human UNC93B1 1:2~1:4 Negative Online Inquiry
KO25676 UNC93B1 Knockout cell line (HEK293) Human UNC93B1 1:3~1:6 Negative Online Inquiry
KO25677 UNC93B1 Knockout cell line (A549) Human UNC93B1 1:3~1:4 Negative Online Inquiry

Background

UNC93B1 Gene Knockout Cell Lines are specialized biological tools designed to facilitate the study of immune response mechanisms and intracellular signaling pathways. These cell lines have been genetically engineered to disrupt the UNC93B1 gene, which plays a critical role in the transport of nucleic acids to endosomal signaling platforms, thereby influencing immune recognition and the activation of innate immune receptors. By utilizing these knockout cell lines, researchers can dissect the functions of UNC93B1, elucidating its role in the modulation of antiviral and antibacterial responses.

The key mechanisms of action for UNC93B1 involve its connection to Toll-like receptors (TLRs), which are essential components of the innate immune system. UNC93B1 assists in the proper trafficking of specific TLRs to endosomes, where they recognize pathogen-associated molecular patterns. When this gene is knocked out, researchers can observe resultant changes in immune signaling pathways, making it easier to explore potential therapeutic targets for infections and inflammatory disorders.

The scientific importance of UNC93B1 Gene Knockout Cell Lines extends to both basic research and clinical applications. By providing a controlled environment to study immune dysregulation, these cell lines help researchers better understand the etiology of diseases such as autoimmune conditions and chronic infections. In translational medicine, insights gained from utilizing these models can inform candidate drug development aimed at enhancing or modulating innate immune responses.

What sets UNC93B1 Gene Knockout Cell Lines apart from alternative models is their specificity and reproducibility in imitating immune responses. Compared to traditional methods, our product allows for more precise experimental controls and the ability to closely monitor the repercussions of gene knockout. This capability diminishes the variability often seen with other models, enhancing the reliability of experimental outcomes.

For researchers and clinicians focused on immunology and therapeutic innovations, UNC93B1 Gene Knockout Cell Lines represent a valuable resource that bridges fundamental research with practical applications. Our company has a proven track record in developing high-quality biological tools, leveraging advanced genetic engineering techniques and in-depth expertise to support the needs of the scientific community. With our commitment to innovation and reliability, we empower researchers to explore the complex mechanisms of the immune system more effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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