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UNC5B Knockout Cell Lines

Gene: UNC5B

Official Full Name: unc-5 netrin receptor Bprovided by HGNC

Gene Summary: This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02622 UNC5B Knockout cell line (HCT 116) Human UNC5B 1:2~1:4 Negative Online Inquiry
KO02623 UNC5B Knockout cell line (HEK293) Human UNC5B 1:3~1:6 Negative Online Inquiry

Background

UNC5B Gene Knockout Cell Lines represent a sophisticated biological tool designed for the investigation of the UNC5B gene's role in various physiological and pathological processes. By utilizing CRISPR/Cas9 technology, these cell lines have been precisely engineered to eliminate the expression of the UNC5B gene, facilitating comprehensive studies into its functions in cell signaling, apoptosis, and cancer progression.

The key mechanism behind these knockout cell lines lies in their ability to create a loss-of-function model for the UNC5B gene. Researchers can observe changes in cellular behaviors, including alterations in migration, adhesion, and differentiation, attributed to the absence of UNC5B. This is particularly relevant in studies related to neurobiology and tumor biology, where UNC5B has been implicated in mediating responses to neurotrophic factors and influencing tumor microenvironments.

The scientific importance of UNC5B Gene Knockout Cell Lines cannot be overstated; they provide invaluable insights for both basic research and translational science. In clinical settings, these models may aid in developing targeted therapies by enhancing our understanding of UNC5B's involvement in disease mechanisms, thus paving the way for innovative treatment strategies.

What sets our UNC5B Gene Knockout Cell Lines apart from alternative models is their quality and reliability. Each line undergoes rigorous validation to ensure complete gene knockout and consistent performance across experiments, minimizing variability that can complicate data interpretation. Researchers benefit from a time-efficient and cost-effective resource that accelerates their investigations into gene function and therapeutic targets.

Our company prides itself on its robust expertise in genetic engineering and cell line development, offering a diverse portfolio of high-quality products tailored to meet the needs of the scientific community. By choosing our UNC5B Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful tool that can help unlock new dimensions of genetic research and foster advancements in clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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