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UCN2 Knockout Cell Lines

Gene: UCN2

Official Full Name: urocortin 2provided by HGNC

Gene Summary: This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23817 UCN2 Knockout cell line (HeLa) Human UCN2 1:3~1:6 Negative Online Inquiry
KO23818 UCN2 Knockout cell line (A549) Human UCN2 1:3~1:4 Negative Online Inquiry

Background

UCN2 Gene Knockout Cell Lines represent a sophisticated tool in the realm of molecular biology and genetics, designed to facilitate the study of the Urocortin 2 (UCN2) gene's role in various physiological processes. These cell lines have been genetically modified to disrupt the UCN2 gene, allowing researchers to investigate the consequences of UCN2 absence on cellular functions, signal transduction pathways, and behavioral responses.

The primary function of the UCN2 gene knockout is to enable the analysis of the neuroendocrine system influenced by UCN2, a member of the corticotropin-releasing factor (CRF) family. By investigating these knockout models, scientists can unravel the implications of UCN2 in stress response, metabolism, and neurodevelopmental processes. The knockout mechanism relies on CRISPR-Cas9 technology, providing precise and efficient genomic editing that facilitates reproducibility and reliability in experiments.

The scientific importance of UCN2 gene knockout cell lines extends to both basic and applied research. These cell lines are invaluable for studying the etiology of stress-related disorders and metabolic syndromes, as well as for drug development targeting UCN2 pathways. Furthermore, they can serve as models for understanding the interactions between stress signaling and various neurophysiological responses.

Compared to traditional methods of gene silencing, such as RNA interference, UCN2 gene knockout cell lines offer a permanent genetic alteration, thus providing more stable and long-term analyses. Additionally, their specificity allows for targeted experimentation, minimizing off-target effects common with alternative techniques.

This product is especially valuable to researchers and clinicians aiming to explore the nuances of stress biology, psychiatric disorders, or metabolic regulation. The ability to work with these knockout cell lines opens the door to innovative therapeutic strategies and biomarker discovery.

Our company is dedicated to advancing genetic research through our high-quality biological products, including UCN2 gene knockout cell lines. With our focus on precision and reliability, we aim to empower scientists with the tools necessary to drive forward their research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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