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UBE2S Knockout Cell Lines

Gene: UBE2S

Official Full Name: ubiquitin conjugating enzyme E2 Sprovided by HGNC

Gene Summary: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01559 UBE2S Knockout cell line (HeLa) Human UBE2S 1:3~1:6 Negative Online Inquiry
KO01560 UBE2S Knockout cell line (HCT 116) Human UBE2S 1:2~1:4 Negative Online Inquiry
KO01561 UBE2S Knockout cell line (HEK293) Human UBE2S 1:3~1:6 Negative Online Inquiry
KO01562 UBE2S Knockout cell line (A549) Human UBE2S 1:3~1:4 Negative Online Inquiry

Background

UBE2S Gene Knockout Cell Lines are specialized cellular models in which the UBE2S gene, a key player in the ubiquitin-proteasome pathway, has been functionally silenced through targeted genetic modification. This innovative product enables researchers to investigate the precise roles of UBE2S in cellular processes, including protein degradation, cell cycle regulation, and response to stress signals. By utilizing CRISPR/Cas9 or similar gene editing technologies, these cell lines provide a robust platform for studying the implications of UBE2S dysregulation in various human diseases, particularly cancer.

The fundamental mechanism of UBE2S involves its role as an E2 ubiquitin-conjugating enzyme, facilitating the transfer of ubiquitin moieties to substrate proteins. This process plays a critical role in maintaining cellular homeostasis by regulating protein turnover and signaling pathways. The UBE2S Gene Knockout Cell Lines allow for a detailed examination of these mechanisms and their downstream effects, making them invaluable in both basic research and therapeutic development.

Scientifically, these cell lines are essential for elucidating the molecular underpinnings of UBE2S-related pathways, paving the way for novel interventions in oncology and other fields. By providing a clear model system to study UBE2S function and its impact on cell biology, these knockout lines offer significant advantages over traditional, less specific methods of gene manipulation. They enable accurate, reproducible results in a defined cellular context, which is crucial for high-stakes research environments.

The unique selling points of UBE2S Gene Knockout Cell Lines lie in their targeted approach to gene disruption and the high fidelity of gene editing, which provides researchers with a powerful tool to advance their experiments, leading to potentially groundbreaking discoveries. Their use in clinical research can facilitate the identification and validation of new biomarkers and therapeutic targets.

As a company dedicated to advancing scientific research, we leverage our extensive expertise in genetic engineering and cell biology to provide high-quality tools like the UBE2S Gene Knockout Cell Lines. By choosing our products, researchers can enhance their investigations while benefiting from our commitment to innovation and excellence in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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