Gene: UBE2D1
Official Full Name: ubiquitin conjugating enzyme E2 D1provided by HGNC
Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03778 | UBE2D1 Knockout cell line (HeLa) | Human | UBE2D1 | 1:3~1:6 | Negative | Online Inquiry |
KO03779 | UBE2D1 Knockout cell line (HCT 116) | Human | UBE2D1 | 1:2~1:4 | Negative | Online Inquiry |
KO03780 | UBE2D1 Knockout cell line (HEK293) | Human | UBE2D1 | 1:3~1:6 | Negative | Online Inquiry |
KO03781 | UBE2D1 Knockout cell line (A549) | Human | UBE2D1 | 1:3~1:4 | Negative | Online Inquiry |
UBE2D1 Gene Knockout Cell Lines represent a tailored set of genetically modified cells engineered to eliminate the expression of the UBE2D1 gene, which encodes a crucial E2 ubiquitin-conjugating enzyme involved in protein degradation pathways. These cell lines serve as an invaluable tool for researchers looking to study the functional roles of UBE2D1 in cellular processes such as protein turnover, cell cycle regulation, and stress responses.
The primary mechanism of action of these knockout cell lines lies in their ability to allow for the detailed investigation of the UBE2D1 gene's influence on ubiquitination, a key post-translational modification that dictates protein stability and degradation. By utilizing advanced gene-editing techniques, such as CRISPR-Cas9, these cell lines provide a precise and effective model for unraveling the complexities associated with dysregulated ubiquitin-proteasome signaling, a feature often implicated in various diseases, including cancer and neurodegenerative disorders.
The scientific importance of UBE2D1 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They are an exceptional resource for exploring the implications of altered protein homeostasis in health and disease, facilitating drug discovery efforts aimed at targeting ubiquitin-related pathways. Furthermore, these tools are crucial for elucidating the signaling mechanisms that could lead to novel therapeutic strategies.
What distinguishes our UBE2D1 Gene Knockout Cell Lines from other alternatives is their comprehensive validation and the availability of extensive supporting data demonstrating their functional efficacy. Our product not only provides a reliable platform for hypothesis testing but also comes backed by extensive technical support and detailed user manuals, enhancing ease of use for laboratories at all levels.
For researchers, clinicians, and companies involved in genomic and proteomic studies, investing in UBE2D1 Gene Knockout Cell Lines means gaining access to a sophisticated model that bridges basic research with clinical applications, ultimately contributing to advancements in understanding and treating diseases influenced by ubiquitination pathways. Our company specializes in delivering high-quality biological models and reagents to the scientific community, underscoring our commitment to enabling groundbreaking discoveries in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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