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UBAC1 Knockout Cell Lines

Gene: UBAC1

Official Full Name: UBA domain containing 1provided by HGNC

Gene Summary: Enables polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Involved in protein maturation and protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31891 UBAC1 Knockout cell line (HeLa) Human UBAC1 1:3~1:6 Negative Online Inquiry
KO31892 UBAC1 Knockout cell line (HCT 116) Human UBAC1 1:2~1:4 Negative Online Inquiry
KO31893 UBAC1 Knockout cell line (HEK293) Human UBAC1 1:3~1:6 Negative Online Inquiry
KO31894 UBAC1 Knockout cell line (A549) Human UBAC1 1:3~1:4 Negative Online Inquiry

Background

UBAC1 Gene Knockout Cell Lines are specially engineered cellular models that lack the expression of the UBAC1 gene, which is known to play crucial roles in protein regulation and cellular stress response. This innovative product enables researchers to investigate the functional relevance of UBAC1 in various biological processes, including cellular differentiation, apoptosis, and immune response. The knockout is achieved using advanced CRISPR/Cas9 gene-editing technology, ensuring precise and efficient alteration of the target gene, which allows for clear interpretations of its biological functions.

The key mechanism of UBAC1 Gene Knockout Cell Lines revolves around the complete absence of the UBAC1 protein, facilitating studies on how the loss of this protein affects cellular pathways and interactions. Researchers can utilize these cell lines to elucidate the molecular mechanisms underpinning UBAC1's involvement in disease models, particularly in cancer research, where UBAC1 is implicated in tumor progression and metastasis.

From a scientific perspective, the availability of these knockout cell lines is pivotal for advancing our understanding of UBAC1’s role in pathophysiology, providing a robust tool for drug screening, gene function studies, and the development of targeted therapeutic strategies. Compared to alternative models, such as overexpression systems or wild-type cell lines, the UBAC1 Gene Knockout Cell Lines deliver an unparalleled advantage by allowing researchers to observe phenotypic changes resulting from the direct omission of the gene, rather than compensatory changes that might occur in overexpression models.

The value of this product is undeniable for researchers and clinicians focused on genetic functions and their impact on health and disease, as it presents a streamlined approach to studying gene behavior with high fidelity. Furthermore, this product underlines our company’s commitment to delivering cutting-edge research tools backed by extensive expertise in genetic engineering and cell line development, ensuring our clients receive reliable and innovative solutions for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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