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TYW1 Knockout Cell Lines

Gene: TYW1

Official Full Name: tRNA-yW synthesizing protein 1 homologprovided by HGNC

Gene Summary: Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO12904 TYW1 Knockout cell line (HeLa) Human TYW1 1:3~1:6 Negative Online Inquiry
KO12905 TYW1 Knockout cell line (HCT 116) Human TYW1 1:2~1:4 Negative Online Inquiry
KO12906 TYW1 Knockout cell line (HEK293) Human TYW1 1:3~1:6 Negative Online Inquiry
KO12907 TYW1 Knockout cell line (A549) Human TYW1 1:3~1:4 Negative Online Inquiry

Background

TYW1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate the study of TYW1 (tRNA-tyrosylcorboxylic acid synthetase) function and its associated pathways in various biological contexts. These cell lines are created through targeted gene editing techniques, such as CRISPR/Cas9, resulting in the complete ablation of the TYW1 gene. This knockout model is integral for researchers aiming to elucidate the role of TYW1 in translation, cellular stress responses, and cancer biology.

The primary function of TYW1 involves the modification of tRNA molecules, impacting protein synthesis and cellular metabolism. By generating these knockout cell lines, researchers can analyze the resultant phenotypic changes and assess how the absence of TYW1 influences cellular processes such as proliferation, differentiation, and apoptosis. This functional analysis is crucial for understanding the pathological implications of TYW1 dysregulation in diseases, including various forms of cancer.

The scientific importance of TYW1 Gene Knockout Cell Lines extends into both basic and applied research, as they offer a valuable tool for drug discovery and therapeutic interventions targeting aberrant signaling pathways. In clinical settings, these cell lines can be employed for screening potential treatments or understanding patient-specific responses to therapies.

One of the unique advantages of TYW1 Gene Knockout Cell Lines is their high specificity and reproducibility, allowing researchers to confidently attribute observed effects to the loss of TYW1 without confounding variables. This contrasts sharply with traditional pharmacological approaches that often suffer from off-target effects and variability. Additionally, these cell lines are compatible with various experimental techniques, including high-throughput screening, CRISPR validation studies, and functional genomics.

For researchers and clinicians focused on advancing knowledge in molecular biology and therapeutic development, the TYW1 Gene Knockout Cell Lines present an unparalleled resource that enhances experimental rigor and enables deeper insight into key biological processes. Our company is committed to providing top-tier genetic models and expertise in molecular biology assays, ensuring our clients have access to cutting-edge tools for their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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