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TUBB4A Knockout Cell Lines

Gene: TUBB4A

Official Full Name: tubulin beta 4A class IVaprovided by HGNC

Gene Summary: This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31935 TUBB4A Knockout cell line (HeLa) Human TUBB4A 1:3~1:6 Negative Online Inquiry
KO31936 TUBB4A Knockout cell line (HCT 116) Human TUBB4A 1:2~1:4 Negative Online Inquiry
KO31937 TUBB4A Knockout cell line (HEK293) Human TUBB4A 1:3~1:6 Negative Online Inquiry
KO31938 TUBB4A Knockout cell line (A549) Human TUBB4A 1:3~1:4 Negative Online Inquiry

Background

TUBB4A Gene Knockout Cell Lines are specially engineered cell lines that feature a targeted deletion of the TUBB4A gene, which encodes for the beta-tubulin protein crucial for microtubule formation and cellular structure. These knockout models are vital for studying the specific role of TUBB4A in cellular processes, including cell division, intracellular transport, and signal transduction. By eliminating the gene's expression, researchers can observe the resultant phenotypic changes and better understand the gene's contributions to various biological functions.

The mechanisms behind TUBB4A's functionality involve its participation in the assembly of microtubules, which are essential for maintaining cell shape and enabling motility. The knockout of TUBB4A provides a unique platform to investigate abnormal microtubule dynamics associated with neurodegenerative diseases, cancer, and other pathologies linked to cytoskeletal dysfunction. Thus, these cell lines are invaluable tools for researchers engaged in genetic studies, drug discovery, and therapeutic development.

Compared to traditional cell lines, TUBB4A Gene Knockout Cell Lines offer the distinct advantage of providing a precise model to dissect the implications of TUBB4A loss in a controlled environment. This specificity reduces variability and increases the reproducibility of experimental outcomes, making it easier to draw conclusive results. Furthermore, the elimination of confounding pathways through knockout technology facilitates targeted investigations into the role of TUBB4A in tumorogenesis and other disorders.

For researchers and clinicians, utilizing TUBB4A Gene Knockout Cell Lines can accelerate discoveries by providing a robust, genetically defined background for experimental manipulations. Moreover, our commitment to quality and innovation in biological product development ensures that users receive reliable cell lines that have been thoroughly validated for consistency and performance. Our expertise in the field assures that these cell lines can effectively support your research endeavors and advance our understanding of critical biological processes.

Please note that all services are for research use only. Not intended for any clinical use.

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