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TTC8 Knockout Cell Lines

Gene: TTC8

Official Full Name: tetratricopeptide repeat domain 8provided by HGNC

Gene Summary: This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. A mutation in this gene has also been implicated in nonsyndromic retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28896 TTC8 Knockout cell line (HeLa) Human TTC8 1:3~1:6 Negative Online Inquiry
KO28897 TTC8 Knockout cell line (HCT 116) Human TTC8 1:2~1:4 Negative Online Inquiry
KO28898 TTC8 Knockout cell line (HEK293) Human TTC8 1:3~1:6 Negative Online Inquiry
KO28899 TTC8 Knockout cell line (A549) Human TTC8 1:3~1:4 Negative Online Inquiry

Background

TTC8 Gene Knockout Cell Lines are specifically engineered cellular models that enable the study of the TTC8 gene's role in cellular processes. These cell lines have undergone precise genetic modification to inactivate the TTC8 gene, resulting in a knockout phenotype that lacks the normal functionality of this gene. This technology facilitates an in-depth examination of the physiological and pathological consequences of TTC8 loss, aiding researchers in understanding its implications in various biological pathways.

Key functions of the TTC8 gene include its involvement in ciliary function and signaling pathways crucial for cellular communication and development. The mechanisms by which these knockout cell lines exert their effects include alterations in signaling cascades and disrupted cellular homeostasis, which are critical for studying diseases associated with ciliary dysfunction, such as ciliopathies. By employing these knockout cell lines, researchers can directly observe the impact of TTC8 deletion on cell proliferation, differentiation, and the overall behavior of the cells, which can provide insights into potential therapeutic targets.

The scientific importance of TTC8 Gene Knockout Cell Lines extends to both academic and clinical research settings, particularly in the realm of genomics and molecular biology. They serve as valuable tools for elucidating the pathogenic mechanisms underlying genetic disorders and developing new therapeutic interventions. The specificity of these cell lines allows scientists to gain at a granular level, leading to potential advancements in personalized medicine.

One of the primary advantages of our TTC8 Gene Knockout Cell Lines is their high specificity and reproducibility compared to traditional methods such as RNA interference. Additionally, these cell lines are extensively validated to ensure consistent performance across various experimental conditions, providing reliable data for researchers. Their use can significantly cut down the time and effort typically required for extensive gene editing procedures, allowing for more streamlined workflow and accelerated discovery.

For researchers and clinicians aiming to delve into the intricate workings of the TTC8 gene and its multifaceted roles, the TTC8 Gene Knockout Cell Lines present an invaluable asset. With the growing demand for advanced genetic research tools, our product stands out as a premium offering rooted in extensive expertise in genetic engineering and cell biology.

Our company is dedicated to delivering high-quality biological products that meet the evolving needs of scientists and healthcare professionals, ensuring innovation and excellence in every offering.

Please note that all services are for research use only. Not intended for any clinical use.

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