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TSR3 Knockout Cell Lines

Gene: TSR3

Official Full Name: TSR3 ribosome maturation factorprovided by HGNC

Gene Summary: Enables 18S rRNA aminocarboxypropyltransferase activity. Involved in enzyme-directed rRNA pseudouridine synthesis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30573 TSR3 Knockout cell line (HeLa) Human TSR3 1:3~1:6 Negative Online Inquiry
KO30574 TSR3 Knockout cell line (HCT 116) Human TSR3 1:2~1:4 Negative Online Inquiry
KO30575 TSR3 Knockout cell line (HEK293) Human TSR3 1:3~1:6 Negative Online Inquiry
KO30576 TSR3 Knockout cell line (A549) Human TSR3 1:3~1:4 Negative Online Inquiry

Background

TSR3 Gene Knockout Cell Lines are specifically engineered cellular models characterized by the targeted deletion of the TSR3 gene, known for its critical role in ribosomal biogenesis and cellular stress response processes. By employing advanced CRISPR/Cas9 technology, these cell lines allow researchers to elucidate the intricate functions and regulatory mechanisms associated with TSR3, thus serving as invaluable tools in the study of gene function and signal transduction pathways.

The key mechanism underlying the functionality of TSR3 knockout cell lines lies in their ability to mimic conditions of genetic deficiency, enabling the study of phenotypic changes, cellular adaptation mechanisms, and the potential compensatory pathways activated in response to the absence of TSR3. In research settings, these models can be instrumental in uncovering the molecular underpinnings of diseases related to ribosomal dysfunction, such as certain cancers and genetic disorders.

The scientific importance of these cell lines extends to both basic and translational research applications, providing insights that can influence therapeutic strategies. Their ability to facilitate high-throughput screening for drug candidates targeting related pathways enhances their utility in preclinical studies. Researchers can effectively translate their findings into clinical implications by revealing new therapeutic targets or biomarkers.

Compared to conventional wild-type cell lines, TSR3 Gene Knockout Cell Lines offer distinct advantages in specificity and reproducibility, ensuring consistently precise results. This genetic precision alleviates concerns associated with off-target effects common in pharmacological studies, allowing for more reliable data interpretation.

For researchers and clinicians who seek clarity in gene function exploration and drug discovery processes, TSR3 Gene Knockout Cell Lines represent a robust and reliable solution. By choosing this product, users gain access to a vital resource that combines scientific rigor with innovative technology, ensuring that their research is both meaningful and impactful.

Our company prides itself on its expertise in developing cutting-edge biological products. With a dedicated focus on quality and precision, we are committed to providing researchers with the tools necessary to advance discoveries in genetics and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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