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TSPAN8 Knockout Cell Lines

Gene: TSPAN8

Official Full Name: tetraspanin 8provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01670 TSPAN8 Knockout cell line (HeLa) Human TSPAN8 1:3~1:6 Negative Online Inquiry
KO01671 TSPAN8 Knockout cell line (HCT 116) Human TSPAN8 1:2~1:4 Negative Online Inquiry

Background

TSPAN8 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the TSPAN8 gene, which encodes a transmembrane protein implicated in various physiological processes including cell adhesion, proliferation, and signaling. These cell lines serve as crucial tools for examining the functional role of TSPAN8 in cellular mechanisms and disease states, particularly in tumor biology and the metastatic process.

The key function of TSPAN8 Gene Knockout Cell Lines lies in their ability to facilitate the study of TSPAN8's impact on cell behavior and the underlying molecular pathways. By providing a complete absence of the TSPAN8 protein, these cell lines allow researchers to delineate the gene's contribution to cell motility, invasion, and interaction with the extracellular matrix. This mechanistic insight is obtained through various assays, such as migration and invasion studies, which reveal how TSPAN8 modulation can alter the tumor microenvironment and cellular communication.

Scientifically, TSPAN8 is recognized for its involvement in cancer progression, making these knockout cell lines highly relevant in translational research for understanding malignancies. They stand at the forefront of preclinical studies aiming to identify novel therapeutic targets and evaluate anti-cancer strategies. Researchers can utilize these knockout models to validate the biological significance of TSPAN8 in different cancer types, thereby advancing personalized medicine approaches.

One of the standout advantages of our TSPAN8 Gene Knockout Cell Lines compared to alternative models is the precision of knockout technology, which ensures complete and functional ablation of the target gene. This specificity allows for more robust and reproducible results in experiments, contributing to more reliable data for downstream applications. Additionally, our lines are meticulously characterized for purity and functionality, ensuring that researchers can trust the integrity of their results.

For researchers and clinicians, the value of TSPAN8 Gene Knockout Cell Lines is evident as they provide an unprecedented opportunity to explore TSPAN8's roles without the confounding effects often present in wild-type models. With our established expertise in developing advanced biological products, we offer comprehensive support for these cell lines, including protocols, customization options, and technical assistance, empowering users to maximize their research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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