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TSPAN12 Knockout Cell Lines

Gene: TSPAN12

Official Full Name: tetraspanin 12provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29146 TSPAN12 Knockout cell line (HeLa) Human TSPAN12 1:3~1:6 Negative Online Inquiry
KO29147 TSPAN12 Knockout cell line (HCT 116) Human TSPAN12 1:2~1:4 Negative Online Inquiry
KO29148 TSPAN12 Knockout cell line (HEK293) Human TSPAN12 1:3~1:6 Negative Online Inquiry
KO29149 TSPAN12 Knockout cell line (A549) Human TSPAN12 1:3~1:4 Negative Online Inquiry

Background

TSPAN12 Gene Knockout Cell Lines are specially engineered cellular models that have had the TSPAN12 gene precisely inactivated or disrupted. This innovative tool allows researchers to study the biological implications of TSPAN12 gene functionality through the lens of gene deficiency. TSPAN12 is known for its role in cell signaling pathways, particularly in the context of developing diseases, including retinal degeneration and various cancers. By leveraging these knockout cell lines, scientists can gain invaluable insights into the mechanistic roles of TSPAN12 in cellular processes such as proliferation, differentiation, and migration.

The key mechanism involves the CRISPR-Cas9 gene-editing technology, which allows for specific and efficient targeting of the TSPAN12 gene, leading to its knockout. Researchers typically observe phenotypic changes in the knockout cell lines, providing a clear contrast to wild-type cell lines. This distinction is crucial for validating hypotheses regarding the gene’s functions and its contributions to pathology.

In terms of scientific importance, TSPAN12 Gene Knockout Cell Lines serve as essential tools in both basic research and translational medicine. They can be used to discover potential therapeutic targets, enabling the development of novel treatments for TSPAN12-related conditions. Furthermore, these cell lines facilitate drug screening and toxicity tests, optimizing the path from bench to bedside.

The advantages of TSPAN12 Gene Knockout Cell Lines over traditional cell models include their precise gene alteration, consistency in experimental results, and the ability to create isogenic models for comparative studies. These features streamline research processes and enhance reproducibility.

For researchers and clinicians alike, the value of these knockout cell lines lies in their ability to elucidate gene functions rapidly and accurately, providing a profound understanding of underlying mechanisms in health and disease.

Our extensive expertise in gene editing and commitment to producing high-quality biological products ensures that our TSPAN12 Gene Knockout Cell Lines meet the rigorous standards required in modern laboratories, thereby supporting your groundbreaking research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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