Gene: TRPC1
Official Full Name: transient receptor potential cation channel subfamily C member 1provided by HGNC
Gene Summary: The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34926 | TRPC1 Knockout cell line (HeLa) | Human | TRPC1 | 1:3~1:6 | Negative | Online Inquiry |
KO34927 | TRPC1 Knockout cell line (HCT 116) | Human | TRPC1 | 1:2~1:4 | Negative | Online Inquiry |
KO34928 | TRPC1 Knockout cell line (HEK293) | Human | TRPC1 | 1:3~1:6 | Negative | Online Inquiry |
KO34929 | TRPC1 Knockout cell line (A549) | Human | TRPC1 | 1:3~1:4 | Negative | Online Inquiry |
TRPC1 Gene Knockout Cell Lines are genetically modified cellular models designed to specifically disrupt the expression of the Transient Receptor Potential Canonical 1 (TRPC1) gene. This product serves as a vital tool for researchers investigating the physiological and pathological roles of TRPC1 in various biological systems. The _TRPC1_ gene encodes a member of the TRP ion channel family, which is pivotal for regulating calcium influx into cells, impacting numerous cellular functions such as muscle contraction, neurotransmitter release, and cell proliferation.
The key mechanism by which these knockout cell lines operate involves the elimination of TRPC1 protein expression, thereby allowing researchers to dissect the contributions of TRPC1 to calcium signaling pathways and related cellular responses. By employing these cell lines in experimental setups, scientists can elucidate the functional consequences of TRPC1 depletion and explore its implications in diseases such as heart failure, hypertension, and various malignancies.
In terms of scientific importance, TRPC1 Gene Knockout Cell Lines offer unparalleled advantages in pharmacological research and drug discovery, particularly for therapies targeting ion channel modulations. The ability to study the effects of TRPC1 deletion on cellular activities enhances understanding of ion channel interactions and their contributions to disease mechanisms. Compared to conventional cell lines, these knockout models provide a more physiologically relevant context, resulting in more accurate data that can drive meaningful results in both basic and applied research settings.
The unique selling points of TRPC1 Gene Knockout Cell Lines include their ready-to-use nature, high reproducibility, and the specificity of TRPC1 gene targeting, which minimize off-target effects commonly seen with alternative approaches such as chemical inhibitors or RNA interference techniques. These characteristics ensure that researchers obtain consistent and reliable results, thereby enhancing the quality of their investigations.
For researchers and clinicians focused on dissecting calcium signaling intricacies and developing targeted therapies, TRPC1 Gene Knockout Cell Lines present an invaluable resource. This product not only facilitates groundbreaking research but also supports clinical advancements that can translate to novel therapeutic strategies.
With our company’s extensive expertise in developing high-quality biological tools, we are committed to providing innovative solutions that empower researchers in their quest to unravel complex biological questions. Our products meet rigorous quality standards, ensuring that our customers can rely on them for pioneering research and impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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