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TRMT12 Knockout Cell Lines

Gene: TRMT12

Official Full Name: tRNA methyltransferase 12 homologprovided by HGNC

Gene Summary: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13010 TRMT12 Knockout cell line (HeLa) Human TRMT12 1:3~1:6 Negative Online Inquiry
KO13011 TRMT12 Knockout cell line (HCT 116) Human TRMT12 1:2~1:4 Negative Online Inquiry
KO13012 TRMT12 Knockout cell line (HEK293) Human TRMT12 1:3~1:6 Negative Online Inquiry
KO13013 TRMT12 Knockout cell line (A549) Human TRMT12 1:3~1:4 Negative Online Inquiry

Background

TRMT12 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional role of the TRMT12 gene, which is implicated in various biological processes, including RNA modification and cellular stress responses. These knockout cell lines are created through advanced CRISPR/Cas9 technology, resulting in the complete inactivation of the TRMT12 gene, allowing researchers to observe the consequent phenotypic and molecular alterations.

The primary function of TRMT12 involves its role in transfer RNA (tRNA) modification, a critical process that ensures the fidelity of protein translation. By knocking out the TRMT12 gene, researchers can effectively investigate the subsequent effects on tRNA integrity, translation efficiency, and overall cellular function. This enables a deeper understanding of how disruptions in tRNA modification can contribute to diseases such as cancer or genetic disorders.

The scientific importance of TRMT12 Gene Knockout Cell Lines lies in their versatility and applicability in both research and clinical settings. These models serve as essential tools for elucidating the molecular mechanisms underlying RNA biology and disease states, thereby paving the way for potential therapeutic developments targeting tRNA modifications.

Compared to alternative models, TRMT12 Gene Knockout Cell Lines offer distinct advantages, including high specificity in gene disruption, a robust and reproducible experimental framework, and compatibility with a broad range of assays. Researchers can implement these cell lines to explore novel hypotheses in their investigations, enabling rapid progress in the understanding of gene function and its implications in human health.

By choosing TRMT12 Gene Knockout Cell Lines, researchers and clinicians are equipped with a powerful resource for advancing their studies in molecular biology and translational medicine. Our company prides itself on delivering cutting-edge genetic tools backed by rigorous scientific validation, ensuring that our customers receive high-quality products that enhance their research capabilities and support the next generation of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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