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TRIM69 Knockout Cell Lines

Gene: TRIM69

Official Full Name: tripartite motif containing 69provided by HGNC

Gene Summary: This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25577 TRIM69 Knockout cell line (HeLa) Human TRIM69 1:3~1:6 Negative Online Inquiry
KO25578 TRIM69 Knockout cell line (HCT 116) Human TRIM69 1:2~1:4 Negative Online Inquiry
KO25579 TRIM69 Knockout cell line (A549) Human TRIM69 1:3~1:4 Negative Online Inquiry

Background

TRIM69 Gene Knockout Cell Lines are genetically modified cell lines featuring precise deletions in the TRIM69 gene, an essential member of the tripartite motif (TRIM) protein family known for its role in immune response and cellular signaling pathways. These engineered cell lines serve as powerful tools for investigating the functional implications of TRIM69 deficiency and elucidating the gene's involvement in various biological processes, including inflammatory responses and autophagy regulation.

The functionality of TRIM69 Gene Knockout Cell Lines is rooted in their unique genetic makeup, which allows scientists to perform comparative studies between knockout and wild-type cell lines. This comparison facilitates a clearer understanding of the gene's contribution to disease states and cellular behaviors. Additionally, these cell lines can be employed in drug development and target validation workflows, where the influence of therapeutic compounds on cellular mechanisms can be more accurately assessed in the absence of TRIM69-mediated effects.

The scientific importance of TRIM69 Gene Knockout Cell Lines extends to both research and clinical applications. They are particularly valuable in immunology, cancer research, and studies focused on autoimmune disorders. By providing a platform for in-depth analysis of TRIM69’s role in pathological conditions, these cell lines enable researchers to develop innovative treatment strategies based on detailed genetic insights.

The advantages of using TRIM69 Gene Knockout Cell Lines compared to traditional cell lines or other gene-editing approaches include their specificity and reliability in gene disruption. Unlike transient knockdowns that may only yield temporary effects, these stable knockout cell lines ensure consistent and reproducible gene deletion, allowing for long-term studies without the interference of TRIM69 activity.

For researchers and clinicians focused on understanding complex cellular mechanisms and developing targeted therapies, TRIM69 Gene Knockout Cell Lines offer unparalleled value. They provide an accessible and effective means of dissecting the roles of specific genes in health and disease, enhancing translational research efforts.

Our company specializes in providing high-quality biological products, including expertly characterized gene knockout cell lines. With a commitment to scientific excellence and innovation, we empower researchers to achieve their goals in advancing biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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