Gene: TRIM68
Official Full Name: tripartite motif containing 68provided by HGNC
Gene Summary: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13047 | TRIM68 Knockout cell line (HeLa) | Human | TRIM68 | 1:3~1:6 | Negative | Online Inquiry |
KO13048 | TRIM68 Knockout cell line (HCT 116) | Human | TRIM68 | 1:2~1:4 | Negative | Online Inquiry |
KO13049 | TRIM68 Knockout cell line (HEK293) | Human | TRIM68 | 1:3~1:6 | Negative | Online Inquiry |
KO13050 | TRIM68 Knockout cell line (A549) | Human | TRIM68 | 1:3~1:4 | Negative | Online Inquiry |
TRIM68 Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of the TRIM68 gene’s role in various biological processes and diseases. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines allow for the complete and permanent deletion of the TRIM68 gene, providing researchers with invaluable tools to investigate the consequences of loss-of-function mutations. The knockout of TRIM68 offers insights into cellular pathways this gene regulates, including those involved in immune response, stress response, and cell proliferation.
The primary function of TRIM68 lies in its roles as an E3 ubiquitin ligase, which impacts protein degradation pathways critical for maintaining cellular homeostasis. By creating knockout cell lines, researchers can elucidate the distinct contributions of TRIM68 to various cellular functions, particularly under pathological conditions, thereby advancing our understanding of diseases such as cancer and autoimmune disorders.
These cell lines yield significant scientific value in both research and clinical applications. They serve as robust models for drug discovery, enabling the evaluation of therapeutic strategies targeting TRIM68-associated pathways. Furthermore, they can assist in biomarker identification for disease prognosis and treatment response.
Compared to alternative models, TRIM68 Gene Knockout Cell Lines offer superior specificity and reproducibility. They eliminate the confounding effects of TRIM68 expression, providing clearer insights compared to knockdown methods that may leave residual activity. Additionally, the stability of these knockout lines ensures consistent performance across experiments, further validating research findings.
Investing in TRIM68 Gene Knockout Cell Lines empowers researchers and clinicians to deepen their understanding of gene function and its implications in health and disease. Our company, recognized for its commitment to scientific innovation and product excellence, draws on extensive expertise in genetic engineering to deliver high-quality biological tools essential for modern biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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