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TRIM26 Knockout Cell Lines

Gene: TRIM26

Official Full Name: tripartite motif containing 26provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05974 TRIM26 Knockout cell line (HeLa) Human TRIM26 1:3~1:6 Negative Online Inquiry
KO05975 TRIM26 Knockout cell line (HCT 116) Human TRIM26 1:2~1:4 Negative Online Inquiry
KO05976 TRIM26 Knockout cell line (HEK293) Human TRIM26 1:3~1:6 Negative Online Inquiry
KO05977 TRIM26 Knockout cell line (A549) Human TRIM26 1:3~1:4 Negative Online Inquiry

Background

TRIM26 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the TRIM26 gene, a member of the tripartite motif (TRIM) family of proteins known for their roles in various cellular processes, including immune response, oncogenesis, and autophagy. These knockout cell lines are generated through advanced gene-editing techniques such as CRISPR/Cas9, allowing for precise ablation of the TRIM26 gene, thus enabling researchers to investigate the gene's specific functions and its broader implications in cellular signaling pathways.

Functionally, TRIM26 is involved in mediating immune responses and regulating inflammation, making the knockout cell lines invaluable for research into autoimmune diseases, cancer biology, and infectious disease mechanisms. By examining cells devoid of TRIM26, scientists can uncover the nuanced roles this protein plays in cellular regulation and its contributions toward disease pathology. This underpins the scientific importance of TRIM26 knockout lines in providing a clearer understanding of complex biological interactions.

The unique selling points of TRIM26 Gene Knockout Cell Lines lie in their specificity and reliability compared to alternative models, such as wild-type cell lines or non-targeted knockout models. Researchers benefit from the pure genetic background of these lines, minimizing confounding variables that could skew experimental results. This specificity enhances reproducibility in experiments designed to elucidate the functional roles of the TRIM26 gene.

The value of TRIM26 Gene Knockout Cell Lines extends beyond basic research; these models are essential for the development of targeted therapies, potentially aiding in the advancement of precision medicine. As researchers, clinicians, and pharmaceutical developers strive to better understand and treat diseases influenced by the TRIM26 gene, these cell lines serve as critical tools in their investigative arsenals.

With a strong background in genetic engineering and cell biology, our company provides high-quality, validated fine-tuned biological materials designed to meet the rigorous demands of modern research. We are committed to supporting scientific innovation that leads to breakthrough discoveries and therapeutic advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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