Gene: TRAF4
Official Full Name: TNF receptor associated factor 4provided by HGNC
Gene Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00447 | TRAF4 Knockout cell line (HCT 116) | Human | TRAF4 | Negative | Online Inquiry | |
KO33034 | TRAF4 Knockout cell line (HeLa) | Human | TRAF4 | 1:3~1:6 | Negative | Online Inquiry |
KO33035 | TRAF4 Knockout cell line (HEK293) | Human | TRAF4 | 1:3~1:6 | Negative | Online Inquiry |
KO33036 | TRAF4 Knockout cell line (A549) | Human | TRAF4 | 1:3~1:4 | Negative | Online Inquiry |
TRAF4 Gene Knockout Cell Lines are genetically engineered cellular models created to investigate the biological functions and molecular mechanisms of the TRAF4 gene, a critical player in various signaling pathways, including those related to immune responses, cellular proliferation, and apoptosis. These cell lines are designed using advanced CRISPR-Cas9 knockout technology, which ensures precise and efficient deletion of the TRAF4 gene, allowing researchers to study its absence and the resulting phenotypic and biochemical changes.
The key function of these TRAF4 knockout cell lines lies in their ability to serve as a platform for understanding the TRAF4-mediated signaling cascades. By removing TRAF4, researchers can explore its role in modulating TNF receptor signaling and its implications in inflammatory responses or tumorigenesis. The manipulation of this gene can aid in elucidating pathways involved in various diseases, making these cell lines invaluable for fundamental research as well as drug development.
Scientifically, the TRAF4 Gene Knockout Cell Lines are crucial tools in both academic and clinical research settings. They provide insights into the molecular underpinnings of diseases, including cancers and autoimmune disorders, facilitating the development of targeted therapies. These cell lines are particularly potent for applications involving drug screening and validation of therapeutic targets, contributing significantly to the advancement of precision medicine.
One of the unique selling points of our TRAF4 Gene Knockout Cell Lines is their robustness and ease of use compared to traditional knockdown methods such as RNA interference, which often face issues with off-target effects and transient expression. Our cell lines are established in various cellular backgrounds, providing versatility for different research needs and allowing for more reliable and reproducible results.
For researchers and clinicians, investing in TRAF4 Gene Knockout Cell Lines means acquiring a powerful tool for groundbreaking research. These cell lines not only streamline experimental workflows but also enhance the legitimacy of data through their engineered specificity.
With years of expertise in cellular biology and genetic engineering, our company is committed to providing high-quality, cutting-edge biological tools that empower scientists to unlock the mysteries of gene functions. We pride ourselves on continually advancing our product offerings to meet the evolving needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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