Gene: TRAF3IP2
Official Full Name: TRAF3 interacting protein 2provided by HGNC
Gene Summary: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31563 | TRAF3IP2 Knockout cell line (HeLa) | Human | TRAF3IP2 | 1:3~1:6 | Negative | Online Inquiry |
KO31564 | TRAF3IP2 Knockout cell line (HCT 116) | Human | TRAF3IP2 | 1:2~1:4 | Negative | Online Inquiry |
KO31565 | TRAF3IP2 Knockout cell line (HEK293) | Human | TRAF3IP2 | 1:3~1:6 | Negative | Online Inquiry |
KO31566 | TRAF3IP2 Knockout cell line (A549) | Human | TRAF3IP2 | 1:3~1:4 | Negative | Online Inquiry |
TRAF3IP2 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the TRAF3IP2 gene, which encodes a protein implicated in the regulation of various cellular signaling pathways, particularly those related to immune response and inflammation. By precisely knocking out this gene, researchers can study the resultant phenotypic changes and elucidate the role of TRAF3IP2 in cellular processes, including the activation of immune cells and their responses to pathogens.
The primary function of these knockout cell lines is to provide a controlled environment for investigating the biological consequences of TRAF3IP2 loss. Mechanistically, the absence of TRAF3IP2 influences signaling cascades involving NF-kB and MAPK pathways, which are crucial for immune activation and regulation. This enables scientists to delineate how the gene contributes to immune system function and to assess its potential roles in inflammatory diseases, autoimmune disorders, and even cancer.
The scientific importance of TRAF3IP2 Gene Knockout Cell Lines lies in their ability to serve as a tool for discovery in both basic and translational research. In a clinical context, they may provide insights that lead to novel therapeutic strategies targeting TRAF3IP2-related pathways, enhancing the development of precision medicine approaches.
Compared to conventional models, the unique selling points of our TRAF3IP2 Gene Knockout Cell Lines include their specificity and reliability, ensuring reproducibility in experiments. Unlike CRISPR/Cas9 generated models that may exhibit off-target effects, our carefully validated knockout lines offer a true representation of the functional consequences of gene disruption.
For researchers and clinicians, the value of these cell lines lies in their potential to unravel complex biological mechanisms and identify new drug targets or biomarkers related to immune function and disease pathology. By utilizing TRAF3IP2 Gene Knockout Cell Lines, scientists can achieve more meaningful data that propel research forward.
Our company possesses extensive expertise in genetic engineering and cellular model development, providing high-quality biological products that empower advancements in biotechnology and biomedical research. With a commitment to innovation and scientific integrity, we strive to support our customers in their quest for breakthroughs that can transform health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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