Gene: TRAF2
Official Full Name: TNF receptor associated factor 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10960 | TRAF2 Knockout cell line (HeLa) | Human | TRAF2 | 1:3~1:6 | Negative | Online Inquiry |
KO10961 | TRAF2 Knockout cell line (HCT 116) | Human | TRAF2 | 1:2~1:4 | Negative | Online Inquiry |
KO10962 | TRAF2 Knockout cell line (HEK293) | Human | TRAF2 | 1:3~1:6 | Negative | Online Inquiry |
KO10963 | TRAF2 Knockout cell line (A549) | Human | TRAF2 | 1:3~1:4 | Negative | Online Inquiry |
TRAF2 Gene Knockout Cell Lines are expertly engineered cellular models designed to study the role of the TNF Receptor-Associated Factor 2 (TRAF2) gene in various biological processes. These knockout cell lines have been generated using advanced CRISPR/Cas9 gene-editing technology, ensuring that the TRAF2 gene is systematically inactivated. Through the elimination of TRAF2, researchers can investigate its contributions to critical signaling pathways, including those related to immune response, apoptosis, and inflammation.
The primary function of TRAF2 is to mediate signal transduction downstream of several receptors, impacting the NF-κB and MAPK pathways. By utilizing TRAF2 Gene Knockout Cell Lines, scientists can elucidate unconventional functions of TRAF2 in cell survival and differentiation. This unique model allows for direct measurement of cellular responses to stimuli by comparing knockout cells against wild-type counterparts, enabling enhanced understanding of complex pathophysiological processes.
The scientific significance of these knockout cell lines extends to numerous research and clinical applications, particularly in the fields of cancer biology, immunology, and drug development. Researchers can utilize these models to explore TRAF2's involvement in tumorigenesis and its potential role as a therapeutic target. TRAF2 Gene Knockout Cell Lines offer a robust platform for high-throughput screening of pharmacological agents that may mitigate or exploit TRAF2-related pathways.
Compared to traditional cell lines or other gene-editing platforms, our TRAF2 knockout models provide superior specificity and reproducibility, minimizing off-target effects often associated with earlier methodologies. They are engineered to maintain physiological relevance, ensuring that research outcomes are translatable to in vivo systems.
For researchers and clinicians, these knockout cell lines represent a significant leap forward in dissecting TRAF2-related signaling in disease states. Their availability facilitates pioneering discoveries that may lead to novel therapeutic strategies, contributing to advancements in clinical care.
With years of expertise in biological product development, our company is dedicated to providing high-quality, genetically modified cell lines that cater to the needs of modern biological research. We strive to support scientists and clinicians in their quest for knowledge and innovation in health sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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