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TPRN Knockout Cell Lines

Gene: TPRN

Official Full Name: taperinprovided by HGNC

Gene Summary: This locus encodes a sensory epithelial protein. It was defined by linkage analysis in three Pakistani families to lie between D9S1818 (centromeric) and D9SH6 (telomeric). Mutations at this locus have been associated with autosomal recessive deafness. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13091 TPRN Knockout cell line (HeLa) Human TPRN 1:3~1:6 Negative Online Inquiry
KO13092 TPRN Knockout cell line (HCT 116) Human TPRN 1:2~1:4 Negative Online Inquiry
KO13093 TPRN Knockout cell line (HEK293) Human TPRN 1:3~1:6 Negative Online Inquiry
KO13094 TPRN Knockout cell line (A549) Human TPRN 1:3~1:4 Negative Online Inquiry

Background

TPRN Gene Knockout Cell Lines are specialized mammalian cell lines that have been genetically modified to eliminate the expression of the TPRN gene, a crucial component implicated in various cellular processes and disease mechanisms. These cell lines serve as valuable tools for researchers aiming to better understand the functional role of TPRN in cellular biology, signal transduction pathways, and its potential involvement in pathological conditions.

The key mechanism underlying these knockout cell lines involves the use of CRISPR-Cas9 technology, which enables precise editing of the genomic DNA. By introducing a double-strand break at the location of the TPRN gene, researchers can achieve a frame shift or deletion that leads to the complete loss of its function. This targeted gene disruption facilitates the study of the phenotypic outcomes associated with the absence of TPRN, including alterations in cell growth, differentiation, and response to various stimuli.

The scientific importance of TPRN Gene Knockout Cell Lines lies in their applications across a spectrum of research fields, including cancer biology, neurobiology, and regenerative medicine. These cell lines provide a clean model to investigate molecular pathways that may contribute to disease development and progression, thereby facilitating drug discovery and therapeutic targeting.

One of the main advantages of our TPRN Gene Knockout Cell Lines compared to other genetic models is the reliability and specificity of the CRISPR technology employed, which minimizes off-target effects and ensures reproducibility. Additionally, these cell lines come with detailed characterization data, which allows researchers to have confidence in their experimental outcomes, as opposed to less well-documented alternatives in the market.

For researchers and clinicians alike, TPRN Gene Knockout Cell Lines offer unprecedented opportunities to elucidate the roles of TPRN in various biological contexts, providing insights that may lead to innovative therapies and treatment approaches. Our commitment to producing high-quality, validated biological products positions us as a trusted partner in advancing scientific discovery. By choosing our TPRN Gene Knockout Cell Lines, you are equipping yourself with a powerful resource that enhances your research capabilities and paves the way for breakthroughs in understanding and treating complex diseases.

Please note that all services are for research use only. Not intended for any clinical use.

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