Gene: TPCN1
Official Full Name: two pore segment channel 1provided by HGNC
Gene Summary: Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08028 | TPCN1 Knockout cell line (HeLa) | Human | TPCN1 | 1:3~1:6 | Negative | Online Inquiry |
KO08029 | TPCN1 Knockout cell line (HCT 116) | Human | TPCN1 | 1:2~1:4 | Negative | Online Inquiry |
KO08030 | TPCN1 Knockout cell line (HEK293) | Human | TPCN1 | 1:3~1:6 | Negative | Online Inquiry |
KO08031 | TPCN1 Knockout cell line (A549) | Human | TPCN1 | 1:3~1:4 | Negative | Online Inquiry |
TPCN1 Gene Knockout Cell Lines are engineered cellular models lacking the TPCN1 gene, which encodes the two-pore channel nucleotide 1 protein. This protein is integral in regulating cellular responses to stimuli, particularly in mediating calcium and sodium ion flux in response to purinergic signaling. The mechanistic functioning of these knockout cell lines allows researchers to study the physiological roles of TPCN1 in detail, providing insights into its impact on cellular homeostasis and signal transduction pathways.
The scientific importance of TPCN1 Gene Knockout Cell Lines lies in their application in both fundamental research and clinical settings. Researchers utilize these cell lines to investigate the gene's role in various biological processes, including cell proliferation, differentiation, and various disease states such as cardiovascular and neurodegenerative disorders. Additionally, these cell lines serve as valuable tools for drug discovery, enabling the identification of potential therapeutic targets associated with TPCN1-mediated pathways.
Compared to conventional cell lines, TPCN1 Gene Knockout Cell Lines offer distinct advantages by providing a more accurate representation of the gene's functional absence, thereby allowing for more precise interpretation of experimental results. This specificity enhances the reproducibility and reliability of scientific studies, making them indispensable resources for academic institutions and biotechnology companies alike.
The value of TPCN1 Gene Knockout Cell Lines to researchers and clinicians is underscored by their potential to deepen the understanding of disease mechanisms and to aid in the development of tailored therapeutic strategies. By utilizing these knockout models, users can explore the physiological consequences of TPCN1 loss in an environment that mimics the intricate dynamics of human biology.
Our company specializes in providing high-quality genetic models, reflecting our commitment to advancing biomedical research. With unmatched expertise in gene editing technologies, we ensure that our TPCN1 Gene Knockout Cell Lines meet rigorous scientific standards, empowering researchers with the tools they need to drive innovation and discovery in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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