Gene: TP53INP2
Official Full Name: tumor protein p53 inducible nuclear protein 2provided by HGNC
Gene Summary: The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13100 | TP53INP2 Knockout cell line (HeLa) | Human | TP53INP2 | 1:3~1:6 | Negative | Online Inquiry |
KO13101 | TP53INP2 Knockout cell line (HCT 116) | Human | TP53INP2 | 1:2~1:4 | Negative | Online Inquiry |
KO13102 | TP53INP2 Knockout cell line (HEK293) | Human | TP53INP2 | 1:3~1:6 | Negative | Online Inquiry |
KO13103 | TP53INP2 Knockout cell line (A549) | Human | TP53INP2 | 1:3~1:4 | Negative | Online Inquiry |
TP53INP2 Gene Knockout Cell Lines are genetically engineered cellular systems designed to elucidate the roles and functions of the TP53INP2 gene in various biological processes. These knockout cell lines offer a powerful tool for researchers to investigate the gene's involvement in cellular responses to stress, apoptosis, and cancer development by providing a controlled environment in which the gene's expression is completely eliminated. The mechanism of action involves precise genome editing techniques, such as CRISPR-Cas9, which disrupt the TP53INP2 gene, enabling the study of phenotypic changes in cellular behavior and signaling pathways.
The scientific significance of TP53INP2 Gene Knockout Cell Lines lies in their applications in cancer research and therapeutic development. TP53INP2 has been implicated in various signaling pathways related to tumor suppression and cellular homeostasis, making these knockout models crucial for understanding the gene's contributions to oncogenesis and potential therapeutic targets. Furthermore, these cell lines facilitate the testing of drug responses and the investigation of cellular adaptations to treatment, enhancing the translational potential of preclinical studies.
Compared to conventional cell lines, TP53INP2 knockout cell lines offer specific advantages by providing a more accurate representation of the genetic landscape involved in the pathophysiology of diseases. They allow researchers to eliminate confounding factors present in wild-type cell lines, revealing insights that may lead to the discovery of novel biomarkers or drug targets.
For researchers and clinicians focusing on cancer biology or therapeutic interventions, the availability of TP53INP2 Gene Knockout Cell Lines presents an invaluable resource. Their ability to elucidate the intricate roles of the TP53INP2 gene can drive the development of innovative strategies aimed at combating cancer and improving patient outcomes.
Our company specializes in advanced genetic tools and resources, ensuring high-quality and reliable products that empower researchers to make significant breakthroughs in their studies. We are committed to supporting the scientific community through our expertise in genetic engineering and our extensive range of specialized cell lines.
Please note that all services are for research use only. Not intended for any clinical use.
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