Gene: TOMM34
Official Full Name: translocase of outer mitochondrial membrane 34provided by HGNC
Gene Summary: The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04548 | TOMM34 Knockout cell line (HeLa) | Human | TOMM34 | 1:3~1:6 | Negative | Online Inquiry |
KO04549 | TOMM34 Knockout cell line (HCT 116) | Human | TOMM34 | 1:2~1:4 | Negative | Online Inquiry |
KO04550 | TOMM34 Knockout cell line (HEK293) | Human | TOMM34 | 1:3~1:6 | Negative | Online Inquiry |
KO04551 | TOMM34 Knockout cell line (A549) | Human | TOMM34 | 1:3~1:4 | Negative | Online Inquiry |
TOMM34 Gene Knockout Cell Lines are genetically modified cell models specifically engineered to disrupt the expression of the Translocase of Outer Mitochondrial Membrane 34 (TOMM34) gene. This innovative tool facilitates the study of mitochondrial function and cellular metabolism by providing researchers with a platform to understand the effects of TOMM34 deficiency on cellular pathways, such as apoptosis, reactive oxygen species production, and mitochondrial morphology. By employing CRISPR-Cas9 technology, these knockout cell lines ensure precise and efficient gene disruption, allowing for the clear assessment of the gene's role within various biological processes.
The functionality of TOMM34 knockout cell lines lies in their ability to elucidate the cellular response to mitochondrial dysfunction, thus enabling scientists to model diseases associated with mitochondrial pathology, including neurodegenerative disorders and certain cancers. In clinical research, these models are invaluable for drug screening and therapeutic development, offering insights into potential treatments and biomarkers associated with TOMM34-related conditions.
What distinguishes TOMM34 Gene Knockout Cell Lines from other cell line products is their specificity and reliability; the knockout efficiency is rigorously verified using genomic analysis, ensuring minimal off-target effects. This reliability promotes confidence in experimental results, making these cell lines ideal for researchers aiming to produce reproducible and publishable findings.
Researchers and clinicians looking to delve into mitochondrial pathophysiology will find these knockout cell lines to be a crucial asset in their investigations. Their capacity to precisely mimic disease states translates into tangible advancements in understanding therapeutic targets and developing novel interventions.
With a commitment to innovation and quality, our company stands at the forefront of genetic engineering technology, continuously expanding our product portfolio to support the cutting-edge research of our clients in academia and industry alike.
Please note that all services are for research use only. Not intended for any clinical use.
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