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TNRC6A Knockout Cell Lines

Gene: TNRC6A

Official Full Name: trinucleotide repeat containing adaptor 6Aprovided by HGNC

Gene Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27642 TNRC6A Knockout cell line (HeLa) Human TNRC6A 1:3~1:6 Negative Online Inquiry
KO27643 TNRC6A Knockout cell line (HCT 116) Human TNRC6A 1:2~1:4 Negative Online Inquiry
KO27644 TNRC6A Knockout cell line (HEK293) Human TNRC6A 1:3~1:6 Negative Online Inquiry
KO27645 TNRC6A Knockout cell line (A549) Human TNRC6A 1:3~1:4 Negative Online Inquiry

Background

TNRC6A Gene Knockout Cell Lines are a meticulously engineered biological product designed to facilitate the study of gene function and regulation, specifically pertaining to the TNRC6A gene, which is pivotal in the process of RNA silencing and post-transcriptional gene expression. These cell lines have been constructed using cutting-edge CRISPR/Cas9 technology, allowing for precise editing of the TNRC6A gene, leading to its complete knockout.

The primary function of TNRC6A is its involvement in the microRNA (miRNA) pathway, acting as an essential scaffold for mRNA degradation. By creating knockout cell lines, researchers gain invaluable insights into the roles that TNRC6A plays in various cellular processes, including RNA stability, translation regulation, and overall gene expression control. This tool is particularly relevant for studies focusing on cancer biology, neurobiology, and any disease where miRNA-mediated gene regulation is disrupted.

In clinical settings, the TNRC6A Gene Knockout Cell Lines can be instrumental in identifying potential therapeutic targets and in the validation of new drug candidates that influence RNA silencing mechanisms. The ability to observe the effects of TNRC6A depletion on cellular behavior offers a direct approach to understanding disease mechanisms and developing intervention strategies.

Compared to traditional gene knockdown methods, such as siRNA or shRNA, our knockout cell lines provide a permanent and stable platform for research, eliminating the variability associated with transient transfections. Additionally, they are rigorously characterized and validated for their effectiveness, ensuring high-quality data generation.

The value of the TNRC6A Gene Knockout Cell Lines lies in their ability to yield reliable and reproducible results, empowering researchers and clinicians to draw more conclusive scientific insights. These cell lines represent a vital resource for academic institutions and biotech companies alike, supporting progress in RNA research and therapeutic development.

Our company is dedicated to advancing research in molecular biology, providing high-quality biological products and expertise that researchers can trust. We stand by our commitment to foster scientific innovation through reliable tools that enhance understanding and discovery in the field of genetics.

Please note that all services are for research use only. Not intended for any clinical use.

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