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TNK1 Knockout Cell Lines

Gene: TNK1

Official Full Name: tyrosine kinase non receptor 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02867 TNK1 Knockout cell line (HeLa) Human TNK1 1:3~1:6 Negative Online Inquiry
KO02868 TNK1 Knockout cell line (HCT 116) Human TNK1 1:2~1:4 Negative Online Inquiry
KO02869 TNK1 Knockout cell line (HEK293) Human TNK1 1:3~1:6 Negative Online Inquiry
KO02870 TNK1 Knockout cell line (A549) Human TNK1 1:3~1:4 Negative Online Inquiry

Background

TNK1 Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the expression of the TNK1 gene, which encodes a member of the tyrosine kinase family involved in various cellular signaling pathways. These knockout cell lines serve as crucial tools for researchers, allowing for the investigation of the functional roles of TNK1 in processes such as cell proliferation, differentiation, and apoptosis. By utilizing CRISPR-Cas9 gene editing techniques, these cell lines provide a precise and efficient means of generating specific genetic modifications, facilitating in-depth studies of TNK1’s contributions to cellular mechanisms and disease.

One of the key functions of TNK1 is its involvement in the regulation of cellular signaling pathways, including those linked to cancer progression and immune response. By employing TNK1 Gene Knockout Cell Lines in preclinical studies, researchers can elucidate the consequences of TNK1 loss on cellular behavior, investigate its roles in oncogenesis, and assess potential therapeutic targets. Importantly, these tools are invaluable in drug discovery, enabling scientists to screen for compounds that may exert differential effects on TNK1-expressing versus knockout cells.

The TNK1 Gene Knockout Cell Lines offer several advantages over alternative models, including enhanced specificity in gene targeting and reduced off-target effects. Moreover, they are complemented by extensive characterization documentation, allowing for reproducibility and confidence in experimental outcomes. These cell lines stand out due to their ability to mimic the pathophysiological conditions of various diseases, offering an improved understanding of TNK1's roles in human health and disease contexts.

For researchers and clinicians focused on cellular signaling and therapeutic interventions, TNK1 Gene Knockout Cell Lines provide a powerful, ready-to-use resource that significantly enriches their experimental repertoire. Our company's dedication to excellence in bioresearch, backed by years of experience in developing high-quality genetic models, underscores our commitment to fostering advanced scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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