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TMOD3 Knockout Cell Lines

Gene: TMOD3

Official Full Name: tropomodulin 3provided by HGNC

Gene Summary: Enables cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06960 TMOD3 Knockout cell line (HeLa) Human TMOD3 1:3~1:6 Negative Online Inquiry
KO06961 TMOD3 Knockout cell line (HCT 116) Human TMOD3 1:2~1:4 Negative Online Inquiry
KO06962 TMOD3 Knockout cell line (HEK293) Human TMOD3 1:3~1:6 Negative Online Inquiry
KO06963 TMOD3 Knockout cell line (A549) Human TMOD3 1:3~1:4 Negative Online Inquiry

Background

TMOD3 Gene Knockout Cell Lines are precision-engineered cellular models that have had the TMOD3 gene selectively disrupted, allowing for in-depth investigation of its biological roles in various cellular contexts. This knockout approach utilizes advanced CRISPR-Cas9 gene-editing technology, ensuring that researchers can study the resultant phenotypic changes with high fidelity and reproducibility. By eliminating the TMOD3 gene, these cell lines facilitate the analysis of its function in processes such as cytoskeletal dynamics, cellular signaling, and cellular responses to environmental stressors.

The primary mechanism by which TMOD3 influences cellular behavior revolves around its role as a tropomodulin, a crucial actin filament capping protein that regulates actin polymerization and stabilization. In various studies, the absence of TMOD3 has been linked to alterations in cell morphology, motility, and proliferation, making these knockout cell lines invaluable tools in cell biology research. The scientific importance of TMOD3 gene knockout cell lines extends to their applications in cancer research, neurobiology, and studies of cardiomyocyte development, where understanding actin dynamics is pivotal.

One of the unique advantages of TMOD3 Gene Knockout Cell Lines over traditional models lies in their precise gene editing, which eliminates background variability often seen in RNA interference methods. Researchers can achieve more consistent and interpretable results, ultimately leading to more robust experimental conclusions. Furthermore, these cell lines serve as an indispensable resource for developing targeted therapies that modulate actin dynamics, thereby offering promising pathways for innovative treatment options.

Our company specializes in the production of high-quality, genetically-engineered cell lines and has a proven track record in the field of genetic research. With our expertise and commitment to advancing biological science, the TMOD3 Gene Knockout Cell Lines stand out as a vital asset for researchers and clinicians seeking to unlock the complexities of cellular mechanisms and develop next-generation therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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