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TMEM70 Knockout Cell Lines

Gene: TMEM70

Official Full Name: transmembrane protein 70provided by HGNC

Gene Summary: This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13296 TMEM70 Knockout cell line (HeLa) Human TMEM70 1:3~1:6 Negative Online Inquiry
KO13297 TMEM70 Knockout cell line (HCT 116) Human TMEM70 1:2~1:4 Negative Online Inquiry
KO13298 TMEM70 Knockout cell line (HEK293) Human TMEM70 1:3~1:6 Negative Online Inquiry
KO13299 TMEM70 Knockout cell line (A549) Human TMEM70 1:3~1:4 Negative Online Inquiry

Background

TMEM70 Gene Knockout Cell Lines are specialized cellular models engineered to lack the TMEM70 gene, which is critical in mitochondrial biogenesis and energy metabolism. By creating these knockout cell lines, researchers can effectively study the functional implications of TMEM70 deficiency, particularly its role in mitochondrial disorders and energy production pathways.

The key function of these knockout cell lines resides in their ability to elucidate the molecular mechanisms underpinning TMEM70's contribution to mitochondrial function. By studying these cells, researchers can observe the cellular responses, changes in metabolic profiles, and variations in bioenergetics that arise in the absence of TMEM70. This insight is crucial, as TMEM70 has been implicated in various mitochondrial diseases, providing a relevant model for understanding pathophysiological conditions.

The scientific importance of TMEM70 Gene Knockout Cell Lines spans both basic research and clinical applications. They serve as invaluable tools for drug discovery, offering a platform for screening potential therapeutic agents targeting mitochondrial dysfunction. Additionally, they facilitate the examination of genetic interactions and regulatory networks that involve TMEM70, promoting advancements in genetic therapies and precision medicine.

When compared to alternative models, such as wild-type control lines or models using transient knockdown approaches, the stable and reproducible knockout lines offer enhanced consistency and reliability in experimental outcomes. This stability is essential for longitudinal studies and therapeutic evaluations, significantly improving the quality of research data.

For researchers and clinicians focused on understanding mitochondrial biology and developing targeted therapies, TMEM70 Gene Knockout Cell Lines provide a unique opportunity to advance both scientific knowledge and clinical practice. Our company has extensive expertise in the development and provision of innovative genetic models, ensuring that our customers receive high-quality products tailored to their specific research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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