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TMEM63A Knockout Cell Lines

Gene: TMEM63A

Official Full Name: transmembrane protein 63Aprovided by HGNC

Gene Summary: Enables mechanosensitive monoatomic ion channel activity. Predicted to be involved in surfactant secretion. Located in bounding membrane of organelle; centriolar satellite; and plasma membrane. Implicated in hypomyelinating leukodystrophy 19. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32869 TMEM63A Knockout cell line (HeLa) Human TMEM63A 1:3~1:6 Negative Online Inquiry
KO32870 TMEM63A Knockout cell line (HCT 116) Human TMEM63A 1:2~1:4 Negative Online Inquiry
KO32871 TMEM63A Knockout cell line (HEK293) Human TMEM63A 1:3~1:6 Negative Online Inquiry
KO32872 TMEM63A Knockout cell line (A549) Human TMEM63A 1:3~1:4 Negative Online Inquiry

Background

TMEM63A Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the TMEM63A gene, a critical player in various cellular processes including mechanotransduction, ion homeostasis, and cellular signaling pathways. This product utilizes CRISPR-Cas9 technology to create a complete knockout of the TMEM63A gene, allowing researchers to study the gene's functions and its implications in cellular physiology and disease.

The key mechanism of action involves targeted double-strand breaks introduced by the Cas9 nuclease at specific locations within the TMEM63A gene, leading to insertions or deletions that disrupt the gene's coding sequence. Through this precise editing, these knockout cell lines provide invaluable models for understanding the biological roles of TMEM63A in health and disease. In a research or clinical setting, they can be instrumental in elucidating the gene's involvement in potential pathological states such as neuropathic pain, cardiovascular diseases, and various cancers.

The scientific importance of the TMEM63A Gene Knockout Cell Lines lies in their ability to facilitate novel insights into gene function and molecular interactions, making them an essential tool for drug discovery, functional genomics studies, and personalized medicine approaches. Compared to alternative models, such as transiently transfected cells or less precise gene silencing techniques, these knockout lines ensure stable and reproducible results, thereby improving experimental reliability.

Moreover, these cell lines come with a user-friendly assay protocol and robust support from our experienced scientific team, which enhances usability for researchers at all levels. By selecting our TMEM63A Gene Knockout Cell Lines, researchers and clinicians gain access to a reliable and efficient model system that accelerates their exploration of TMEM63A-associated pathways.

Our company specializes in innovative genetic engineering technologies, providing advanced tools that empower research and clinical advancements. Through unwavering commitment to quality and scientific excellence, we aim to be your partner in unlocking the mysteries of biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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