Gene: TMEM253
Official Full Name: transmembrane protein 253provided by HGNC
Gene Summary: Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13181 | TMEM253 Knockout cell line (HeLa) | Human | TMEM253 | 1:3~1:6 | Negative | Online Inquiry |
KO13182 | TMEM253 Knockout cell line (A549) | Human | TMEM253 | 1:3~1:4 | Negative | Online Inquiry |
TMEM253 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the function of the TMEM253 gene, which is believed to play a significant role in various cellular processes, including membrane dynamics and signal transduction. The generation of these knockout lines enables researchers to study the biological consequences resulting from the loss of TMEM253 expression, elucidating its function in health and disease.
The key mechanism of TMEM253 knockout cell lines lies in their genetic modification achieved via CRISPR-Cas9 technology. This process introduces precise mutations that disable the TMEM253 gene, allowing for the assessment of changes in cell behavior, signaling pathways, and phenotypic expression. By utilizing such cell lines, scientists can conduct detailed studies on the role of TMEM253 in a variety of biological contexts, including cellular differentiation, proliferation, and response to external stimuli, which is crucial for understanding its contribution to pathological conditions.
The scientific importance of TMEM253 Gene Knockout Cell Lines extends to applications in cancer research, immunology, and developmental biology, where deciphering the gene’s function can reveal critical insights into disease mechanisms and potential therapeutic targets. Compared to alternative models such as RNA interference or overexpression lines, which may not fully replicate the gene's loss-of-function effects, the complete knockout provides a clearer understanding of gene function without the influence of residual protein activity.
Researchers and clinicians will find these cell lines particularly valuable as they enable a deeper exploration of the mechanisms underlying various diseases, facilitating the development of innovative treatment strategies. By employing these models, users can enhance the reliability of their experimental data and improve the robustness of their findings.
Our company specializes in providing high-quality biological products tailored for cutting-edge research. With a commitment to advancing scientific discovery, we ensure that our TMEM253 Gene Knockout Cell Lines have been thoroughly validated and produced under stringent quality controls, supporting researchers in their quest to unlock the complexities of human biology.
Please note that all services are for research use only. Not intended for any clinical use.
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