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TMEM237 Knockout Cell Lines

Gene: TMEM237

Official Full Name: transmembrane protein 237provided by HGNC

Gene Summary: The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13193 TMEM237 Knockout cell line (HeLa) Human TMEM237 1:3~1:6 Negative Online Inquiry
KO13194 TMEM237 Knockout cell line (HCT 116) Human TMEM237 1:2~1:4 Negative Online Inquiry
KO13195 TMEM237 Knockout cell line (HEK293) Human TMEM237 1:3~1:6 Negative Online Inquiry
KO13196 TMEM237 Knockout cell line (A549) Human TMEM237 1:3~1:4 Negative Online Inquiry

Background

TMEM237 Gene Knockout Cell Lines are specialized cell lines generated through advanced gene editing techniques that enable the specific inactivation of the TMEM237 gene. This gene encodes a membrane protein thought to be involved in cellular processes such as ion regulation, cellular signaling, and potentially the maintenance of cellular homeostasis. By utilizing CRISPR-Cas9 technology, these cell lines have been precisely engineered to facilitate the study of TMEM237's function and its role in various biological pathways.

The primary mechanism of these knockout cell lines involves the recognition and cleavage of the TMEM237 gene by Cas9 endonuclease, resulting in insertion or deletion mutations that disrupt gene function. As a result, researchers can investigate the downstream effects of this gene's absence, elucidating its contributions to cellular physiology and pathology. These cell lines are especially valuable in studying diseases where TMEM237 may play a critical role, such as neurodegenerative disorders or cancer, allowing for insights into therapeutic targets and biomarker identification.

The scientific importance of TMEM237 Gene Knockout Cell Lines extends into both fundamental research and clinical applications. Researchers can utilize these models to dissect intricate signaling networks and identify potential drug interactions, paving the way for novel therapeutic strategies. Additionally, the cell lines provide a robust platform for drug screening and validation of targets, enhancing translational research efforts.

One of the significant advantages of these specific knockout lines is their ability to provide clear, reproducible results in research, minimizing the confounding variables often encountered with partial gene knockouts or less specific methods like RNA interference. As a result, they represent a more reliable choice for researchers targeting TMEM237's pathways.

For researchers and clinicians committed to understanding cellular functions, the TMEM237 Gene Knockout Cell Lines offer an essential tool that bridges the gap between laboratory research and clinical application. With our company's expertise in gene editing technologies and a portfolio of high-quality biological products, you can trust in the reliability and innovation that our offerings bring to your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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