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TMEM163 Knockout Cell Lines

Gene: TMEM163

Official Full Name: transmembrane protein 163provided by HGNC

Gene Summary: Predicted to enable zinc ion binding activity. Involved in myelination and zinc export across plasma membrane. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Implicated in hypomyelinating leukodystrophy 25. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00268 TMEM163 Knockout cell line (HeLa) Human TMEM163 1:3~1:6 Negative Online Inquiry
KO25686 TMEM163 Knockout cell line (HEK293) Human TMEM163 1:3~1:6 Negative Online Inquiry

Background

TMEM163 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate in-depth research into the role of the TMEM163 gene, which encodes for a transmembrane protein implicated in cellular processes such as ion transport and homeostasis. These knockout cell lines provide a crucial tool for scientists investigating the physiological and pathological aspects related to TMEM163 function, especially concerning diseases where ion dysregulation plays a critical role.

The key function of these cell lines lies in their ability to eliminate the expression of the TMEM163 gene, allowing researchers to observe the resultant phenotypic changes compared to wild-type cells. This knockout model elucidates the gene's biological pathways, offering insights into mechanisms of disease, particularly in neurodegenerative conditions and other ion transport disorders. By using these models, researchers can study how the absence of TMEM163 affects ion dynamics and cellular metabolism at a molecular level.

Scientifically, these cell lines are vital for drug discovery and the development of targeted therapies. They serve as valuable platforms to screen for therapeutic agents that could restore normal function or correct pathological conditions arising from TMEM163 dysregulation. Moreover, the precision of gene knockout technology provides a more accurate reflection of in vivo conditions compared to traditional cell models.

One of the unique advantages of TMEM163 Gene Knockout Cell Lines compared to alternative models is the specificity and reliability they offer. Unlike transient transfection methods that may yield inconsistent knockdown results, these stable knockout cell lines ensure a permanent genetic alteration, allowing long-term studies and reproducibility of results. Additionally, they are developed under rigorous quality control, ensuring consistent performance across different experimental conditions.

For researchers and clinicians, the insight gained from the use of TMEM163 knockout lines is invaluable, promoting advancements in understanding complex diseases while paving the way for novel therapeutic strategies.

At our company, we pride ourselves on our extensive expertise in genetic engineering and innovative biological product development, ensuring that our offerings, including TMEM163 Gene Knockout Cell Lines, meet the highest standards of scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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