Home / TMEM158 Knockout Cell Lines

TMEM158 Knockout Cell Lines

Gene: TMEM158

Official Full Name: transmembrane protein 158provided by HGNC

Gene Summary: Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28641 TMEM158 Knockout cell line (HeLa) Human TMEM158 1:3~1:6 Negative Online Inquiry
KO28642 TMEM158 Knockout cell line (HCT 116) Human TMEM158 1:2~1:4 Negative Online Inquiry
KO28643 TMEM158 Knockout cell line (HEK293) Human TMEM158 1:3~1:6 Negative Online Inquiry
KO28644 TMEM158 Knockout cell line (A549) Human TMEM158 1:3~1:4 Negative Online Inquiry

Background

TMEM158 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functions and regulatory mechanisms associated with the TMEM158 gene. The gene encoding TMEM158 is implicated in various cellular processes, including signal transduction and cellular stress responses. By creating knockout cell lines through precise gene editing techniques, such as CRISPR-Cas9, researchers can effectively explore the downstream effects of TMEM158 deficiency on cellular behavior, metabolism, and gene expression.

The key function of TMEM158 knockout cell lines lies in their ability to elucidate the biological pathways influenced by the TMEM158 protein. Without this gene, cells can exhibit altered responses to external stimuli, including growth factors and stress, providing invaluable insights into the protein's role in these processes. Furthermore, these cell lines serve as a foundational tool for drug testing and therapeutic development by allowing scientists to assess the impact of potential treatments on cells lacking functional TMEM158.

In scientific research and clinical applications, an understanding of the TMEM158 gene is crucial, particularly in areas related to cancer biology and stress-related pathologies. Knockout models enable targeted investigations into disease mechanisms and the exploration of potential interventions to mitigate the effects of TMEM158 dysregulation.

Compared to traditional models, such as wild-type or overexpression systems, TMEM158 knockout cell lines offer distinct advantages, including reduced off-target effects and the ability to study loss-of-function scenarios directly. This specificity bolsters the credibility of research findings, ensuring that studies utilizing these cell lines yield more reliable data.

In the competitive landscape of gene knockout technologies, our advanced methodologies and commitment to creating high-quality cell lines set our TMEM158 knockout models apart. By partnering with us, researchers and clinicians gain access to cutting-edge biological tools that enhance their investigative capabilities. Our expertise in cellular and molecular techniques guarantees that our products meet the highest standards for reliability and performance, facilitating groundbreaking research and advancements in personalized medicine.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.