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TMEM145 Knockout Cell Lines

Gene: TMEM145

Official Full Name: transmembrane protein 145provided by HGNC

Gene Summary: Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13244 TMEM145 Knockout cell line (HCT 116) Human TMEM145 1:2~1:4 Negative Online Inquiry
KO13245 TMEM145 Knockout cell line (HEK293) Human TMEM145 1:3~1:6 Negative Online Inquiry
KO13246 TMEM145 Knockout cell line (A549) Human TMEM145 1:3~1:4 Negative Online Inquiry

Background

TMEM145 Gene Knockout Cell Lines represent a powerful tool for biological research, specifically designed to elucidate the functional roles of the TMEM145 gene within various cellular contexts. These cell lines are meticulously engineered using CRISPR-Cas9 technology to create precise deletions in the TMEM145 gene, thereby allowing researchers to study the consequences of TMEM145 loss on cellular physiology and signaling pathways.

The key mechanism behind the functionality of these knockout cell lines lies in their ability to mimic genetic loss-of-function scenarios, making them invaluable for investigating the gene's role in processes such as cell proliferation, differentiation, and apoptosis. By utilizing these cell lines, scientists can delve into the gene's involvement in diseases where TMEM145 is hypothesized to play a critical role, such as cancer or metabolic disorders. This enables the identification of novel therapeutic targets and facilitates the development of innovative treatment approaches.

The scientific importance of TMEM145 Gene Knockout Cell Lines extends beyond basic research; they serve as essential tools in translational medicine applications, helping bridge the gap between laboratory findings and clinical practice. Their utilization in drug discovery and validation processes can accelerate the identification of potential compounds that effectively modulate TMEM145-related pathways.

Compared to alternative models, such as transient transfection or RNA interference, these knockout cell lines provide a stable and reproducible system for long-term studies, ensuring consistent results across experiments. Furthermore, the specificity of the CRISPR-Cas9 approach allows for precise targeting, minimizing off-target effects and enhancing the reliability of experimental outcomes.

For researchers, clinicians, and biotechnology professionals, the TMEM145 Gene Knockout Cell Lines stand as a vital asset in advancing understanding of gene function and disease mechanisms. With our company’s extensive expertise in genetic engineering and cell line development, we assure the highest quality standards for our biological products, designed to empower your research and accelerate discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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