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TMEM138 Knockout Cell Lines

Gene: TMEM138

Official Full Name: transmembrane protein 138provided by HGNC

Gene Summary: This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22449 TMEM138 Knockout cell line (HeLa) Human TMEM138 1:3~1:6 Negative Online Inquiry
KO22450 TMEM138 Knockout cell line (HCT 116) Human TMEM138 1:2~1:4 Negative Online Inquiry
KO22451 TMEM138 Knockout cell line (HEK293) Human TMEM138 1:3~1:6 Negative Online Inquiry
KO22452 TMEM138 Knockout cell line (A549) Human TMEM138 1:3~1:4 Negative Online Inquiry

Background

TMEM138 Gene Knockout Cell Lines are advanced cellular models engineered to possess a complete inactivation of the TMEM138 gene, which encodes a protein involved in various cellular processes, including cell signaling, membrane dynamics, and potential roles in neurobiology. The creation of these knockout cell lines utilizes CRISPR-Cas9 technology, providing precision in gene editing that allows researchers to investigate the specific functions and regulatory mechanisms associated with TMEM138.

The primary function of the TMEM138 gene entails its purported involvement in cellular responses to stress and its contribution to neuronal function. By studying these knockout cell lines, researchers can elucidate the role of TMEM138 in physiological and pathological contexts, such as neurodegenerative diseases and developmental disorders. This invaluable insight can help probe into mechanisms underpinning diseases, facilitating the identification of potential therapeutic targets and treatments.

From a scientific standpoint, TMEM138 Gene Knockout Cell Lines play a crucial role in translational research and drug discovery, offering a reliable platform for testing hypotheses concerning gene function and interactions in a controlled environment. Compared to traditional models, these cell lines exhibit higher specificity and reproducibility, thus providing more accurate data during experimental assessments.

One of the standout advantages of using TMEM138 knockout cell lines lies in their capacity to reduce off-target effects commonly observed with other genetic manipulation methods. This enhanced reliability makes them a top choice for researchers focused on gene function studies and therapeutic development.

Integrating TMEM138 Gene Knockout Cell Lines into research workflows not only expedites experimental outcomes but also empowers researchers and clinicians with the tools needed to unveil novel pathways and interventions. Our company, with extensive expertise in gene editing technologies and a commitment to supporting scientific advancement, is dedicated to providing high-quality biological products like these knockout cell lines, ensuring that our users have access to cutting-edge tools that drive impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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