Gene: TMEM120B
Official Full Name: transmembrane protein 120Bprovided by HGNC
Gene Summary: Predicted to be involved in fat cell differentiation and protein heterooligomerization. Predicted to be located in membrane and nucleus. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24108 | TMEM120B Knockout cell line (HeLa) | Human | TMEM120B | 1:3~1:6 | Negative | Online Inquiry |
KO24109 | TMEM120B Knockout cell line (HCT 116) | Human | TMEM120B | 1:2~1:4 | Negative | Online Inquiry |
KO24110 | TMEM120B Knockout cell line (HEK293) | Human | TMEM120B | 1:3~1:6 | Negative | Online Inquiry |
KO24111 | TMEM120B Knockout cell line (A549) | Human | TMEM120B | 1:3~1:4 | Negative | Online Inquiry |
TMEM120B Gene Knockout Cell Lines are specialized biological tools designed to facilitate the study of the TMEM120B gene and its associated pathways. By employing CRISPR/Cas9 technology, these cell lines feature a specific and intentional disruption of the TMEM120B gene, allowing researchers to examine its functional role in various biological processes, including cellular stress responses, metabolism, and signaling pathways. This targeted gene knockout enables detailed investigations into the gene's contribution to disease mechanisms, especially in cancer and metabolic disorders.
The functionality of TMEM120B Gene Knockout Cell Lines arises from the intentional disruption of the TMEM120B gene, leading to the elimination of its protein product. This disruption allows for the assessment of changes in cellular behavior and gene expression profiles, thereby offering insights into the gene's involvement in physiological and pathological states. Researchers can use these lines to elucidate compensatory mechanisms in mutant contexts, providing a deeper understanding of gene networks and potential therapeutic targets.
Scientifically, the availability of TMEM120B Gene Knockout Cell Lines is crucial for advancing research in several domains, including molecular biology, genetics, and pharmacology. Their applications extend to drug discovery, where understanding how the loss of TMEM120B function impacts cellular responses can illuminate novel therapeutic pathways and biomarkers.
One of the primary advantages of using TMEM120B Gene Knockout Cell Lines is the precision of the CRISPR/Cas9 gene-editing methodology, which ensures that the knockout is specific and reproducible. Unlike traditional gene knockdown approaches that rely on RNA interference, which may have off-target effects or incomplete suppression, these knockout lines provide a more robust model for gene function analysis.
The value of TMEM120B Gene Knockout Cell Lines lies in their ability to streamline the research process, facilitating quicker and more accurate findings. For researchers and clinicians aiming to explore the biological ramifications of TMEM120B, these cell lines offer a powerful platform for studies that could lead to significant breakthroughs in understanding and treating diseases linked to this gene.
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Please note that all services are for research use only. Not intended for any clinical use.
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