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TMEM117 Knockout Cell Lines

Gene: TMEM117

Official Full Name: transmembrane protein 117provided by HGNC

Gene Summary: Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25095 TMEM117 Knockout cell line (HeLa) Human TMEM117 1:3~1:6 Negative Online Inquiry
KO25096 TMEM117 Knockout cell line (HCT 116) Human TMEM117 1:2~1:4 Negative Online Inquiry
KO25097 TMEM117 Knockout cell line (HEK293) Human TMEM117 1:3~1:6 Negative Online Inquiry
KO25098 TMEM117 Knockout cell line (A549) Human TMEM117 1:3~1:4 Negative Online Inquiry

Background

TMEM117 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the TMEM117 gene, a product of notable interest due to its involvement in critical cellular processes. These knockout cell lines are meticulously designed to facilitate the study of TMEM117’s role in various biological contexts, including cell proliferation, differentiation, and signaling pathways. By employing CRISPR-Cas9 technology, our cell lines ensure precise gene editing, creating a robust system for functional studies.

The key function of the TMEM117 knockout is to enable researchers to elucidate the biological consequences of gene loss. This includes investigating alterations in metabolic functions, cellular responses to stress, and pathophysiological implications in disease models. The capacity to observe phenotypic changes resulting from the absence of TMEM117 allows scientists to delve deeper into its potential roles in cancer biology, neurological disorders, and other critical conditions.

The scientific importance of these cell lines is underscored by their applications in both basic and translational research. They serve as valuable tools for drug screening, gene therapy research, and developing targeted therapies. By providing insights into the molecular mechanisms mediated by TMEM117, researchers can potentially identify novel therapeutic targets, thereby contributing to advancements in personalized medicine.

Compared to alternative models, our TMEM117 gene knockout cell lines are distinguished by their high fidelity in gene editing and the extensive characterization that supports their use across a range of experimental conditions. They are derived from well-established cell backgrounds, ensuring compatibility with numerous assays and reducing variability in experimental outcomes.

For researchers and clinicians, the value of TMEM117 Gene Knockout Cell Lines lies in their ability to deliver reproducible results that enhance the understanding of complex biological systems. This, combined with our commitment to molecular biology and genetic engineering expertise, underscores our dedication to providing high-quality biological products that support meaningful research outcomes. Our offerings are not just products; they are essential tools that empower researchers to accelerate discovery and innovation in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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