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TMEM109 Knockout Cell Lines

Gene: TMEM109

Official Full Name: transmembrane protein 109provided by HGNC

Gene Summary: Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of programmed cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13262 TMEM109 Knockout cell line (HeLa) Human TMEM109 1:3~1:6 Negative Online Inquiry
KO13263 TMEM109 Knockout cell line (HCT 116) Human TMEM109 1:2~1:4 Negative Online Inquiry
KO13264 TMEM109 Knockout cell line (HEK293) Human TMEM109 1:3~1:6 Negative Online Inquiry
KO13265 TMEM109 Knockout cell line (A549) Human TMEM109 1:3~1:4 Negative Online Inquiry

Background

TMEM109 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the expression of the TMEM109 gene. This innovative product provides researchers with a powerful tool to investigate the functional roles of TMEM109 in various biological processes. By utilizing CRISPR-Cas9 technology, these cell lines serve as an invaluable resource for studying gene function, cell signaling pathways, and interactions with disease mechanisms.

The primary mechanism by which the TMEM109 Gene Knockout Cell Lines operate is through the complete ablation of TMEM109 expression, leading to phenotypic changes that can be readily monitored in a controlled laboratory environment. Researchers can analyze cellular behaviors, including proliferation, differentiation, and response to external stimuli, thereby elucidating the gene's involvement in critical physiological and pathological processes.

The scientific importance of these knockout cell lines extends into both basic research and clinical applications. For example, understanding the role of TMEM109 in cellular metabolism and stress responses can contribute to novel therapeutic strategies for diseases such as cancer or neurodegenerative disorders. In clinical settings, the insights gained from these studies can inform biomarker development and personalized treatment approaches.

Compared to conventional gene silencing methods, such as RNA interference, TMEM109 Gene Knockout Cell Lines provide a more permanent and stable means of gene manipulation. This permanence allows for robust long-term studies and eliminates the variability often associated with transient knockdown techniques. Additionally, the precise genome editing achieved through CRISPR technology yields highly specific knockout models, reducing off-target effects and ensuring research integrity.

For researchers and clinicians striving to advance their understanding of gene function and its implications in health and disease, TMEM109 Gene Knockout Cell Lines represent a high-value addition to their experimental toolkit. With a commitment to quality and innovation, our company specializes in developing cutting-edge biological products designed to empower discovery and accelerate scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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