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TMEM108 Knockout Cell Lines

Gene: TMEM108

Official Full Name: transmembrane protein 108provided by HGNC

Gene Summary: Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13266 TMEM108 Knockout cell line (HEK293) Human TMEM108 1:3~1:6 Negative Online Inquiry

Background

TMEM108 Gene Knockout Cell Lines are specialized cellular models engineered to lack the TMEM108 gene, allowing researchers to study the specific functions and pathways associated with this gene in various biological contexts. The TMEM108 gene encodes a transmembrane protein implicated in various cellular processes, including synaptic function and neuronal development. By utilizing these knockout cell lines, scientists can precisely observe the phenotypic consequences of the absence of TMEM108, including changes in cellular morphology, differentiation pathways, and gene expression profiles.

The primary mechanism behind the functionality of TMEM108 Gene Knockout Cell Lines lies in the systematic deletion of the gene through CRISPR-Cas9 technology or other gene-editing techniques. This genetic disruption facilitates a comprehensive exploration of downstream signaling pathways and interactions with other genetic elements, providing critical insights into both normal physiology and pathological states, such as neurodegeneration or developmental disorders.

These cell lines hold significant scientific importance, serving as invaluable tools in genetics, neuroscience, and pharmacology research. They are particularly useful for studies aimed at elucidating the molecular mechanisms of drugs targeting neurological conditions or the identification of potential biomarkers for diseases involving TMEM108 dysfunction.

Compared to traditional wild-type cell lines, the TMEM108 Gene Knockout Cell Lines present distinct advantages, including improved specificity and controlled experimental conditions, thereby reducing background noise from confounding factors. Their availability enables researchers to design experiments that can yield clearer, more interpretable results, ultimately accelerating the pace of discovery.

Given the rising interest in gene function and the molecular basis of diseases, TMEM108 Gene Knockout Cell Lines are valuable assets for researchers and clinicians aiming to unravel complex biological questions or develop therapeutic strategies. By employing these knockout models, users can harness the power of targeted research to inform translational applications in medicine.

Our company has a strong foundation in providing high-quality biological products tailored for advanced research. We understand the dynamic needs of the scientific community and strive to offer innovative solutions that empower researchers to push the boundaries of their work.

Please note that all services are for research use only. Not intended for any clinical use.

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