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TMBIM6 Knockout Cell Lines

Gene: TMBIM6

Official Full Name: transmembrane BAX inhibitor motif containing 6provided by HGNC

Gene Summary: Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; negative regulation of macromolecule metabolic process; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35051 TMBIM6 Knockout cell line (HeLa) Human TMBIM6 1:3~1:6 Negative Online Inquiry
KO35052 TMBIM6 Knockout cell line (HCT 116) Human TMBIM6 1:2~1:4 Negative Online Inquiry
KO35053 TMBIM6 Knockout cell line (HEK293) Human TMBIM6 1:3~1:6 Negative Online Inquiry
KO35054 TMBIM6 Knockout cell line (A549) Human TMBIM6 1:3~1:4 Negative Online Inquiry

Background

TMBIM6 Gene Knockout Cell Lines represent a pioneering tool in molecular biology designed for the functional analysis of the TMBIM6 gene, which plays a crucial role in the regulation of apoptosis and cellular stress responses. By employing CRISPR-Cas9 technology, these cell lines provide a powerful platform for researchers to dissect the biological functions of TMBIM6 and its implications in various pathophysiological conditions, particularly in cancer and neurodegenerative diseases.

The knockout of the TMBIM6 gene results in the abrogation of its protective effects against apoptosis, providing insights into how this gene modulates cellular survival under stress. This knowledge is pivotal for understanding the mechanisms underlying cell death and survival, offering a foundation for therapeutic interventions that target these pathways. The availability of these knockout cell lines facilitates extensive studies, including high-throughput screening, drug discovery, and mechanistic investigations into cellular stress responses, making them indispensable in both research and clinical settings.

One of the standout advantages of TMBIM6 Gene Knockout Cell Lines is their specificity and reliability compared to traditional knockdown methods, such as RNA interference, which can yield off-target effects and variable expression levels. With a complete gene knockout, researchers can be assured of a consistent and precise model for further experimentation. This specificity enables clearer interpretation of results and enhances reproducibility, critical factors in the scientific community.

For researchers and clinicians, the value of these knockout cell lines lies in their potential to accelerate the understanding of TMBIM6-related pathways, as well as the discovery of novel therapeutic strategies aimed at modulating these pathways for disease intervention.

Our company has a profound commitment to advancing biological research, providing high-quality cell line products enriched with the latest genomic editing technologies. With a wealth of expertise in molecular biology, we are dedicated to supporting the scientific community in their quest for breakthroughs that drive innovation and enhance human health.

Please note that all services are for research use only. Not intended for any clinical use.

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