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TMBIM4 Knockout Cell Lines

Gene: TMBIM4

Official Full Name: transmembrane BAX inhibitor motif containing 4provided by HGNC

Gene Summary: Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22332 TMBIM4 Knockout cell line (HeLa) Human TMBIM4 1:3~1:6 Negative Online Inquiry
KO22333 TMBIM4 Knockout cell line (HCT 116) Human TMBIM4 1:2~1:4 Negative Online Inquiry
KO22334 TMBIM4 Knockout cell line (HEK293) Human TMBIM4 1:3~1:6 Negative Online Inquiry
KO22335 TMBIM4 Knockout cell line (A549) Human TMBIM4 1:3~1:4 Negative Online Inquiry

Background

TMBIM4 Gene Knockout Cell Lines are meticulously engineered cellular models specifically designed to study the role of the TMBIM4 gene, a member of the Bcl-2 family involved in regulating cellular apoptosis and survival. These knockout cell lines provide researchers with invaluable tools to dissect the functional implications of TMBIM4 deletion, elucidating its contributions to various cellular processes, including stress response and programmed cell death. The knockout mechanism is achieved through advanced CRISPR/Cas9 gene-editing technology, ensuring precise and efficient disruption of the TMBIM4 gene while minimizing off-target effects.

The scientific importance of TMBIM4 Gene Knockout Cell Lines lies in their application across a range of research contexts, especially in cancer biology and neurodegenerative disease studies. By utilizing these cell lines, researchers can investigate the gene’s effects on apoptosis pathways, identify potential therapeutic targets, and explore the molecular mechanisms underlying diseases where TMBIM4 functions are compromised. This deepens the understanding of cell survival mechanisms in disease environments, which is pivotal for developing innovative therapies.

What sets our TMBIM4 Gene Knockout Cell Lines apart from alternatives is the robustness of our knockout validation and the comprehensive support provided to our customers, including detailed protocols and expert guidance. These qualities ensure a streamlined experimental process, enhancing researchers' productivity and confidence in the results.

Researchers and clinicians seeking to advance their studies into apoptosis regulation will find significant value in these cell lines, as they offer a more accurate representation of TMBIM4 gene function than conventional approaches. This precision can lead to new insights that significantly impact therapeutic developments and strategies.

Our company prides itself on a commitment to excellence in biological product development, equipped with cutting-edge technology and a team of experienced scientists dedicated to delivering high-quality research tools tailored to the needs of the scientific community. By choosing TMBIM4 Gene Knockout Cell Lines, users are assured of reliability and innovation that empower their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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